Brunty Sarah, Mitchell Brenda, Bou-Zgheib Nadim, Santanam Nalini
Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Department of Obstetrics and Gynecology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Ann Transl Med. 2020 Dec;8(24):1715. doi: 10.21037/atm-20-2449.
Endometriosis is a gynecological disorder that affects 176 million women worldwide and 1 in 10 females in the United States. Endometriosis most often affects women of child-bearing age, with most going undiagnosed. Endometriosis also shares many characteristics common to invasive cancer and has been known to be associated with epithelial ovarian cancer. Ovarian cancer is the 11 most common cancer among women and over 22,000 new cases will be diagnosed within the next year. Women most commonly diagnosed with this cancer are between the ages of 55-64 years, outside the range of the age of women affected with endometriosis. While no known cause of either disease has been established, epigenetic regulation is thought to play a major role in both. This review focuses on epigenetic changes that occur within each individual disease as well as those that are similar in both, suggesting a possible etiological link between the two diseases.
子宫内膜异位症是一种妇科疾病，全球有1.76亿女性受其影响，在美国每10名女性中就有1人患病。子宫内膜异位症最常影响育龄女性，大多数患者未被诊断出来。子宫内膜异位症还具有许多与侵袭性癌症相同的特征，并且已知与上皮性卵巢癌有关。卵巢癌是女性中第11常见的癌症，明年将有超过22000例新病例被诊断出来。最常被诊断出患有这种癌症的女性年龄在55至64岁之间，不在受子宫内膜异位症影响的女性年龄范围内。虽然这两种疾病的病因都尚未明确，但表观遗传调控被认为在两者中都起主要作用。本综述重点关注每种疾病中发生的表观遗传变化以及两者中相似的变化，提示这两种疾病之间可能存在病因学联系。
