Riley Eammon P, Schwarz Corinna, Derman Alan I, Lopez-Garrido Javier
Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Max Planck Institute for Evolutionary Biology, Plön, Germany.
Microb Cell. 2020 Nov 27;8(1):1-16. doi: 10.15698/mic2021.01.739.
Endospore formation has been a rich field of research for more than a century, and has benefited from the powerful genetic tools available in . In this review, we highlight foundational discoveries that shaped the sporulation field, from its origins to the present day, tracing a chronology that spans more than one hundred eighty years. We detail how cell-specific gene expression has been harnessed to investigate the existence and function of intercellular proteinaceous channels in sporulating cells, and we illustrate the rapid progress in our understanding of the cell biology of sporulation in recent years using the process of chromosome translocation as a storyline. Finally, we sketch general aspects of sporulation that remain largely unexplored, and that we envision will be fruitful areas of future research.
一个多世纪以来，芽孢形成一直是一个研究丰富的领域，并且受益于现有的强大遗传工具。在这篇综述中，我们重点介绍了塑造芽孢形成领域的基础发现，从其起源到如今，追溯跨越一百八十多年的时间顺序。我们详细阐述了如何利用细胞特异性基因表达来研究芽孢形成细胞中细胞间蛋白质通道的存在和功能，并且我们以染色体易位过程为线索，说明了近年来我们对芽孢形成细胞生物学理解的快速进展。最后，我们概述了芽孢形成中大体上仍未被探索的方面，并且我们设想这些将是未来研究富有成果的领域。
