Kumar Harsh, Kumar Rajat, Rao R Ranga, Bhardwaj J R
Classified Specialist (Pathology), Transfusion Centre (Eastern Command), Calcutta.
Classified Specialist (Medicine & Haematology), Army Hospital (R&R), New Delhi.
Med J Armed Forces India. 2002 Jan;58(1):27-9. doi: 10.1016/S0377-1237(02)80008-9. Epub 2011 Jul 21.
Immunophenotyping of leukaemias is presently well established. It is invaluable for proper case management [1]. The most useful information on the management of cases of Acute Lymphocytic Leukaemia (ALL) is provided by the detection of the CD 10 marker on the leukaemic cell. The CD 10 positive ALL has since long been associated with a favourable prognosis as compared to the CD 10 negative ALL [1, 2]. As immunophenotyping is resource intensive, the monoclonal antibodies (MO ABS), are not in widespread use in our country. The expenses involved make this procedure prohibitive in most institutions. For this reason, a limited panel of MO ABS has been used in this study, with a special emphasis on the CD 10 marker. A total of 25 cases of ALL were studied. 17 cases were found to be positive for the CD 10 marker (68%). These cases were associated with a favourable prognosis as compared to the CD 10 negative group. Although, the diagnosis of ALL and leukaemias in general, is essentially based on the study of Romanowsky stained smears [3, 4], the additional information provided by the cell surface marker study results in better case management [1].
白血病的免疫表型分析目前已得到充分确立。它对恰当的病例管理非常重要[1]。急性淋巴细胞白血病（ALL）病例管理中最有用的信息是通过检测白血病细胞上的CD 10标志物获得的。长期以来，与CD 10阴性的ALL相比，CD 10阳性的ALL预后较好[1,2]。由于免疫表型分析资源消耗大，单克隆抗体（MO ABS）在我国未广泛使用。相关费用使得该程序在大多数机构中难以承受。因此，本研究使用了一组有限的MO ABS，特别关注CD 10标志物。共研究了25例ALL病例。发现17例CD 10标志物呈阳性（68%）。与CD 10阴性组相比，这些病例预后较好。虽然，ALL及一般白血病的诊断基本上基于罗曼诺夫斯基染色涂片的研究[3,4]，但细胞表面标志物研究提供的额外信息有助于更好地进行病例管理[1]。
