Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Rd., Guangzhou, 510120 Guangdong Province, China.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China.
J Immunol Res. 2020 Dec 30;2020:8835393. doi: 10.1155/2020/8835393. eCollection 2020.
RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biological functions of RNA helicase DHX37 in cancers.
We aim to identify the prognostic value of DHX37 associated with tumor microenvironments in cancers.
DHX37 expression was examined via the Oncomine database and Tumor Immune Estimation Resource (TIMER). We explored the prognostic role of DHX37 in cancers across various databases. Coexpression genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), and fundamental regulators were performed via LinkedOmics. Confirming the prognostic value of DHX37 in liver hepatocellular carcinoma (LIHC) and lung adenocarcinoma (LUAD), we explored the role of DHX37 in infiltrated lymphocytes in cancers using the Gene Expression Profiling Interactive Analysis (GEPIA) and TIMER databases.
Through GO and KEGG analyses, expression of DHX37 was also correlated with complex function-specific networks involving the ribosome and RNA metabolic signaling pathways. In LIHC and LUAD, DHX37 expression showed significant positive correlations with markers of T, myeloid-derived suppressor cells (MDSCs), and T cell exhaustion, contributing to immune tolerance.
These results indicate that DHX37 can serve as a prognostic biomarker in LIHC and LUAD while having an important role in immune tolerance by activating the function of T, MDSC, and T cell exhaustion.
RNA 解旋酶在 RNA 代谢的各个基本方面都具有各种重要功能，不仅可以解开 RNA，还可以干扰 RNA 与蛋白质的相互作用。最近，RNA 解旋酶已被认为是癌症的潜在靶点。迄今为止，尚未对 RNA 解旋酶 DHX37 在癌症中的生物学功能进行详细研究。
我们旨在确定与癌症肿瘤微环境相关的 DHX37 的预后价值。
通过 Oncomine 数据库和 Tumor Immune Estimation Resource（TIMER）检查 DHX37 的表达。我们在各种数据库中探索了 DHX37 在癌症中的预后作用。通过 LinkedOmics 进行共表达基因、基因本体论（GO）和京都基因与基因组百科全书（KEGG）以及基本调控因子的分析。在确认 DHX37 在肝癌（LIHC）和肺腺癌（LUAD）中的预后价值后，我们使用基因表达谱交互式分析（GEPIA）和 TIMER 数据库探索了 DHX37 在癌症浸润淋巴细胞中的作用。
通过 GO 和 KEGG 分析，DHX37 的表达也与涉及核糖体和 RNA 代谢信号通路的复杂功能特异性网络相关。在 LIHC 和 LUAD 中，DHX37 表达与 T 细胞、髓系来源的抑制细胞（MDSC）和 T 细胞耗竭的标志物呈显著正相关，有助于免疫耐受。
这些结果表明，DHX37 可作为 LIHC 和 LUAD 的预后生物标志物，同时通过激活 T、MDSC 和 T 细胞耗竭的功能，在免疫耐受中发挥重要作用。
