Sobecki Janelle N, Dryer Kathryn A, Mahajan Aparna M, Spencer Ryan J
Division of Gynecologic Oncology, University of Wisconsin-Madison School of Medicine and Public Health, United States.
Department of Obstetrics & Gynecology, University of Wisconsin-Madison School of Medicine and Public Health, United States.
Gynecol Oncol Rep. 2020 Dec 25;35:100690. doi: 10.1016/j.gore.2020.100690. eCollection 2021 Feb.
Ovarian cancer typically presents at advanced stage with intra-abdominal metastases. Rarely, ovarian cancer presents with distant metastases with little to no intra-abdominal disease burden. The patient was a BRCA-2 germline mutation carrier diagnosed with a Stage IVB high-grade carcinoma of the fallopian tube following discovery of a right axillary breast mass on screening mammography. Pre-operative imaging was without evidence of metastatic disease in the abdomen or pelvis. She underwent surgical staging followed by adjuvant chemotherapy and maintenance poly-ADP ribose polymerase (PARP) inhibition. She is without evidence of disease 24 months following her surgical staging procedure. An isolated oligo metastasis in the axilla is a rare presentation of ovarian carcinoma. Extra-abdominal metastases can present a diagnostic challenge in ovarian cancer necessitating thorough pathologic and radiologic work-up, particularly in the absence of intra-abdominal disease.
卵巢癌通常在晚期出现腹腔内转移。很少有卵巢癌表现为远处转移，腹腔内疾病负担很小或没有。该患者是一名BRCA-2种系突变携带者，在乳腺钼靶筛查中发现右腋窝乳腺肿块后，被诊断为IVB期高级别输卵管癌。术前影像学检查未发现腹部或盆腔有转移疾病的证据。她接受了手术分期，随后进行辅助化疗和维持性聚ADP核糖聚合酶（PARP）抑制治疗。手术分期术后24个月，她没有疾病证据。腋窝孤立性寡转移是卵巢癌的一种罕见表现。卵巢癌的腹外转移可能带来诊断挑战，需要进行全面的病理和影像学检查，特别是在没有腹腔内疾病的情况下。
