了解严重急性呼吸综合征冠状病毒2（SARS-CoV-2）再次感染对免疫反应环境、实验室检测及2019冠状病毒病（COVID-19）防控措施的影响。
Understanding the implications of SARS-CoV-2 re-infections on immune response milieu, laboratory tests and control measures against COVID-19.
作者信息
Mustapha Jelili Olaide, Abdullahi Idris Nasir, Ajagbe Odunayo O R, Emeribe Anthony Uchenna, Fasogbon Samuel Ayobami, Onoja Solomon Oloche, Ugwu Charles Egede, Umeozuru Chikodi Modesta, Ajayi Folake Olubunmi, Tanko Wudi Natasha, Omosigho Pius Omoruyi, Aliyu Abdulmumuni Samuel, Shuwa Halima Ali, Nwofe Justin Onyebuchi, Dangana Amos, Alaba Ovye, Ghamba Peter Elisha, Ibrahim Yakubu, Aliyu Dorcas, Animasaun Olawale Sunday, Ugboaja Nkechi Blessing, Baba Mallam Mala Alhaji, Abubakar Sharafudeen Dahiru, Aminu Maijidda Saidu, Yahaya Hadiza, Oyewusi Silifat
机构信息
Medical Microbiology Unit, Medical Laboratory Services Department, Lagos State University Teaching Hospital, Ikeja, Lagos State, Nigeria.
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria.
出版信息
Heliyon. 2021 Jan 9;7(1):e05951. doi: 10.1016/j.heliyon.2021.e05951. eCollection 2021 Jan.
Several months after the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), cases of re-infection after recovery were reported. The extent and duration of protective immunity after SARS-CoV-2 infection is not fully understood. As such, the possibility of re-infection with SARS-CoV-2. Furthermore, cases of re-infection were mainly due to different variants or mutant SARS-CoV-2. Following the fast and pandemic-scale spread of COVID-19, mutations in SARS-CoV-2 have raised new diagnostic challenges which include the redesign of the oligonucleotide sequences used in RT-PCR assays to avoid potential primer-sample mismatches, and decrease sensitivities. Since the initial wave of the pandemic, some regions had experienced fresh outbreaks, predisposing people to be susceptible to SARS-CoV-2 re-infection. Hence, this article sought to offer detailed biology of SARS-CoV-2 re-infections and their implications on immune response milieu, diagnostic laboratory tests and control measures against COVID-19.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）出现几个月后，有康复后再次感染的病例报道。SARS-CoV-2感染后保护性免疫的程度和持续时间尚未完全明确。因此，存在再次感染SARS-CoV-2的可能性。此外，再次感染病例主要是由于不同的SARS-CoV-2变体或突变体。随着COVID-19在全球范围内迅速传播，SARS-CoV-2的突变带来了新的诊断挑战，其中包括重新设计逆转录聚合酶链反应（RT-PCR）检测中使用的寡核苷酸序列，以避免潜在的引物-样本错配并降低检测灵敏度。自大流行的第一波以来，一些地区经历了新的疫情爆发，使人们容易再次感染SARS-CoV-2。因此，本文旨在详细阐述SARS-CoV-2再次感染的生物学特性及其对免疫反应环境、诊断实验室检测和COVID-19防控措施的影响。
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