Department of Cardiovascular Intensive Care Unit, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Eur J Cardiothorac Surg. 2021 May 8;59(5):959-966. doi: 10.1093/ejcts/ezaa470.
This study aimed to review surgical experiences in patients with infracardiac total anomalous pulmonary venous connection (TAPVC).
This retrospective study included 63 infants who underwent conventional repair (n = 27) and sutureless repair (n = 36) from 1 February 2009 to 31 June 2019. Kaplan-Meier curves and Cox regressions were applied to analyse the overall survival and risk factors. Cumulative incidence curves and competing risk models were used to evaluate postoperative pulmonary venous obstruction (PVO).
There were 4 hospital deaths and 2 late deaths, and 8 patients experienced postoperative PVO. The survival rates at 30 days, 1 year and 5 years were 95.2%, 90.5% and 90.5%, respectively. The overall survival rate was significantly higher in the sutureless group than that in the conventional group. The cumulative incidence of postoperative PVO in the conventional group was higher than that in the sutureless group. Univariable Cox regression analyses showed that lower surgical weight, increase in preoperative international normalized ratio, prolonged cardiopulmonary bypass time and aortic cross-clamp time and longer duration of postoperative ventilation were associated with higher mortality. Longer cardiopulmonary bypass time, lower preoperative prothrombin activity and the increasing preoperative international normalized ratio before surgical repair were associated with a higher incidence of postoperative PVO.
Both sutureless and conventional repairs for patients with infracardiac TAPVC achieved favourable postoperative outcomes. There was no death in the sutureless repair group. Compared to conventional repair, sutureless repair was associated with lower mortality and lower incidence of restenosis in pulmonary veins and anastomosis.
本研究旨在回顾下心内型完全性肺静脉异位连接(TAPVC)患者的手术经验。
本回顾性研究纳入了 2009 年 2 月 1 日至 2019 年 6 月 31 日期间接受常规修复(n=27)和无缝合修复(n=36)的 63 例婴儿。采用 Kaplan-Meier 曲线和 Cox 回归分析总生存率和风险因素。使用累积发生率曲线和竞争风险模型评估术后肺静脉阻塞(PVO)。
有 4 例院内死亡和 2 例晚期死亡,8 例患者发生术后 PVO。30 天、1 年和 5 年的生存率分别为 95.2%、90.5%和 90.5%。无缝合组的总生存率明显高于常规组。常规组术后 PVO 的累积发生率高于无缝合组。单变量 Cox 回归分析显示,手术体重较低、术前国际标准化比值升高、体外循环时间和主动脉阻断时间延长以及术后通气时间延长与死亡率升高相关。体外循环时间较长、术前凝血酶原活性较低以及手术修复前国际标准化比值升高与术后 PVO 发生率增加相关。
对于下心内型 TAPVC 患者,无缝合和常规修复均获得了良好的术后结果。无缝合修复组无死亡病例。与常规修复相比,无缝合修复与较低的死亡率和较低的肺静脉和吻合口再狭窄发生率相关。