Department of Paediatrics and Melbourne School of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
Neurodisability & Rehabilitation, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Autism Res. 2021 Mar;14(3):582-598. doi: 10.1002/aur.2463. Epub 2021 Jan 24.
A systematic review published in 2013 reported 32% of children on the autism spectrum experience skill loss, known as autistic regression. However, the frequency varied depending on definition and measures used to capture skills. Retrospective parent report and prospective observation indicate loss of language and/or social skills, with motor skills typically unaffected. Our aim was to update the prevalence and age of onset of autistic regression through a meta-analysis of the literature to understand if there have been changes to the reported onset and prevalence since 2010. A systematic literature search was conducted using Medline, Embase, PsycINFO, and the Cochrane Library databases and included studies published from 2010 onward. Risk of bias assessment was performed on included studies. A random effects model was used to calculate the pooled prevalence and age of onset of autistic regression. Ninety-seven studies were included in the systematic review, of which 75 studies involving 33,014 participants had sufficient data for meta-analytic syntheses. The pooled proportion of autistic regression was 30% (95% confidence interval [CI]: 27-32%) but heterogeneity was high (I = 96.91) and did not reduce with sensitivity or subgroup analyses based on study design or clinical differences, respectively. Prevalence varied according to risk of bias (low: 27%) and definition of regression (language: 20%, language/social: 40%, mixed: 30%, and unspecified: 27%). Weighted average age of onset was 19.8 months. Findings from this meta-analysis highlight the importance of developing a standardized definition of autistic regression, and tools to measure this at multiple time points during early childhood development. LAY SUMMARY: About a third of children with Autism Spectrum Disorder experience loss of skills, which is also known as autistic regression. This paper provides an update of the rate of autistic regression in children and the age when they first experience loss of skills, based on current studies. The findings from this review contribute to our understanding of the onset patterns of autistic regression. Unfortunately, studies are not sufficiently similar, making it difficult to provide clear answers on the exact timing or type of regression seen in different children.
一项 2013 年发表的系统评价报告称，32%的自闭症谱系儿童经历技能丧失，即自闭症退行。然而，其频率取决于用于捕捉技能的定义和测量方法。回溯性父母报告和前瞻性观察表明语言和/或社交技能丧失，而运动技能通常不受影响。我们的目的是通过对文献的荟萃分析来更新自闭症退行的流行率和发病年龄，以了解自 2010 年以来报告的发病和流行率是否发生了变化。使用 Medline、Embase、PsycINFO 和 Cochrane 图书馆数据库进行了系统的文献检索，纳入了 2010 年以后发表的研究。对纳入的研究进行了偏倚风险评估。使用随机效应模型计算自闭症退行的汇总流行率和发病年龄。该系统评价纳入了 97 项研究，其中 75 项涉及 33014 名参与者的研究具有足够的数据进行荟萃分析。自闭症退行的汇总比例为 30%（95%置信区间[CI]：27-32%），但异质性很高（I=96.91%），且无法通过敏感性分析或基于研究设计或临床差异的亚组分析来降低。流行率根据偏倚风险（低：27%）和退行定义（语言：20%，语言/社交：40%，混合：30%，未指定：27%）而变化。发病年龄的加权平均值为 19.8 个月。荟萃分析的结果强调了制定自闭症退行标准化定义以及在儿童早期发展的多个时间点测量这一定义的工具的重要性。
以上译文是基于 ChatGPT 生成的，仅供参考。
