Strelkov L A, Stepanenko R N, Mikhaĭlova A A
Biull Eksp Biol Med. 1987 Dec;104(12):703-6.
Using double 3H-thymidine/14C-amino acid label, the influence of myelopeptides (MP) on chromosomal DNA and total protein (without histones) synthesis has been studied in vitro in mouse lymphoid organ cells. It has been shown that MP cause a decrease in DNA labelling and a parallel increase in protein labelling in bone marrow cells and have practically no effect on these two parameters in thymus, lymph node and spleen cells. It has been found that MP have only mitogenic effect on the above-mentioned organ cells, but in combination with 2-mercaptoethanol. The data obtained show that MP possess the properties of cell-differentiating factors.
运用双3H-胸腺嘧啶核苷/14C-氨基酸标记法，在体外对小鼠淋巴器官细胞中骨髓肽（MP）对染色体DNA和总蛋白（不含组蛋白）合成的影响进行了研究。结果表明，MP可使骨髓细胞中的DNA标记减少，同时使蛋白标记平行增加，而对胸腺、淋巴结和脾细胞中的这两个参数几乎没有影响。研究发现，MP对上述器官细胞仅具有促有丝分裂作用，但与2-巯基乙醇联合使用时则不然。所得数据表明，MP具有细胞分化因子的特性。
