Comprehensive Weight Control Center, Division of Endocrinology, Diabetes & Metabolism, Weill Cornell Medical College, 1165 York Avenue, New York, NY, 10065, USA.
Curr Obes Rep. 2021 Jun;10(2):81-89. doi: 10.1007/s13679-021-00425-1. Epub 2021 Jan 25.
Weight regain after bariatric surgery is unfortunately a common occurrence. In this article, we have reviewed the data addressing this clinical problem focusing on pharmacological management of weight regain.
Data from several small, non-randomized, retrospective, and prospective studies provide evidence that a number of pharmacological options, both FDA approved and off-label, are effective in mitigating and managing weight regain after bariatric surgery. There is a suggestion that the optimal time to initiate weight loss medications may be at the time of weight plateau, rather than after weight regain. Adjuvant pharmacotherapy can help treat weight regain after bariatric surgery. Future studies should investigate the optimal timing for starting weight loss medications, as well as the best medication or combinations of medicines, for managing postoperative weight regain in different patient groups, including those who have undergone different types of bariatric surgeries.
不幸的是，减重手术后体重反弹是一种常见现象。本文就减重手术后体重反弹的临床处理，特别是药物治疗进行了综述。
多项小型、非随机、回顾性和前瞻性研究的数据为以下观点提供了证据，即多种药物治疗方案（包括 FDA 批准和非适应证用药）对减轻和控制减重手术后体重反弹有效。有观点认为，开始使用减肥药的最佳时间可能是在体重平台期，而不是在体重反弹之后。辅助药物治疗有助于治疗减重手术后的体重反弹。未来的研究应探讨开始使用减肥药的最佳时机，以及针对不同患者群体（包括接受不同类型减重手术的患者）术后体重反弹的最佳药物或药物组合。
