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Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction.海马亚区对α-突触核蛋白病变的易损性先于神经退行性变和认知功能障碍。
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Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction.海马亚区对α-突触核蛋白病理的易损性先于神经退行性变和认知功能障碍。
bioRxiv. 2023 Apr 12:2023.04.12.536572. doi: 10.1101/2023.04.12.536572.

本文引用的文献

1
Different patterns of hippocampal subfield pathology in Lewy body disease and Alzheimer's disease.路易体病和阿尔茨海默病中海马亚区病理的不同模式。
Neuropathol Appl Neurobiol. 2021 Aug;47(5):705-706. doi: 10.1111/nan.12695. Epub 2021 Feb 5.
2
Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration.应对额颞叶痴呆数字组织病理学分析前变异性的经验方法。
Front Neurosci. 2019 Jul 3;13:682. doi: 10.3389/fnins.2019.00682. eCollection 2019.
3
QuPath: Open source software for digital pathology image analysis.QuPath：用于数字病理学图像分析的开源软件。
Sci Rep. 2017 Dec 4;7(1):16878. doi: 10.1038/s41598-017-17204-5.
4
Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.对美国国立衰老研究所-阿尔茨海默病协会（NIA-AA）阿尔茨海默病神经病理学评估指南的多中心评估
Alzheimers Dement. 2016 Feb;12(2):164-169. doi: 10.1016/j.jalz.2015.07.492. Epub 2015 Aug 29.
5
Distinct α-synuclein strains differentially promote tau inclusions in neurons.不同的 α-突触核蛋白菌株在神经元中差异性地促进 tau 包涵体的形成。
Cell. 2013 Jul 3;154(1):103-17. doi: 10.1016/j.cell.2013.05.057.

Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer's disease.

作者信息

Coughlin David G, Grossman Murray, Trojanowski John Q, Irwin David J

机构信息

Penn Digital Neuropathology Laboratory at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Department of Neurology at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

出版信息

Neuropathol Appl Neurobiol. 2021 Aug;47(5):707-708. doi: 10.1111/nan.12698. Epub 2021 Feb 15.

DOI:10.1111/nan.12698
PMID:33492664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8298266/
Abstract
摘要