Department of Obstetrics and Gynecology, Stellenbosch University, Cape Town, South Africa.
Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Acta Obstet Gynecol Scand. 2021 Jul;100(7):1280-1287. doi: 10.1111/aogs.14100. Epub 2021 Feb 16.
We aimed to assess cognitive function in women with preeclampsia stratified by severity, before and after onset of disease.
Prospective study performed at a referral hospital in Cape Town, South Africa. Pregnant women between 20 and 42 weeks of gestation with eclampsia, pulmonary edema and preeclampsia without severe features, and a normotensive pregnancy were approached. Women were included at diagnosis of preeclampsia or at admission for delivery (women with normotensive pregnancies). Two cognitive assessments, the Cognitive Failure Questionnaire to assess the cognitive function subjectively before inclusion in the study, and Montreal Cognitive Assessment to assess the current cognitive function objectively before discharge from the hospital after delivery, were performed.
We included 61 women with eclampsia, 28 with preeclampsia complicated by pulmonary edema, 38 with preeclampsia without severe features, and 26 with normotensive pregnancies. There was no difference in cognitive function from early pregnancy between groups. Women with eclampsia and preeclampsia complicated by pulmonary edema scored lower on the Montreal Cognitive Assessment at time of discharge compared with women with normotensive pregnancies. The results were attenuated in pulmonary edema after adjustment for confounders.
Women with preeclampsia complicated by pulmonary edema and in particular eclampsia had impaired cognitive function after onset of disease compared with women with normotensive pregnancies. The impairment did not seem to be present before onset of disease. Women with preeclampsia without severe features did not have impaired cognitive function.
我们旨在评估子痫前期严重程度分层的女性在疾病发作前后的认知功能。
这是在南非开普敦的一家转诊医院进行的前瞻性研究。研究纳入了 20 至 42 孕周的子痫、肺水肿和无严重特征的子痫前期以及正常妊娠的孕妇。孕妇在诊断为子痫前期或因分娩而入院时（正常妊娠孕妇）被纳入研究。在研究纳入前，使用认知失败问卷评估认知功能的主观情况；在分娩后出院前，使用蒙特利尔认知评估评估当前认知功能的客观情况。
我们共纳入 61 例子痫、28 例肺水肿合并子痫前期、38 例无严重特征的子痫前期和 26 例正常妊娠孕妇。各组之间在妊娠早期的认知功能无差异。与正常妊娠孕妇相比，子痫和肺水肿合并子痫前期的孕妇在出院时的蒙特利尔认知评估得分较低。在校正混杂因素后，肺水肿的结果减弱。
与正常妊娠孕妇相比，肺水肿合并子痫前期尤其是子痫的女性在疾病发作后认知功能受损。疾病发作前似乎没有认知功能受损。无严重特征的子痫前期的女性认知功能未受损。
