National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, National Engineering Research Center for New Drug and Druggability (Cultivation), Guangdong Province Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
FEBS J. 2021 Nov;288(21):6174-6186. doi: 10.1111/febs.15726. Epub 2021 Feb 13.
Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment involved in the progression and metastasis of cancer. They are intimately involved in angiogenesis and immunosuppression in normal and malignant tissues, as well as pro-fibrotic activities. With the development of immunotherapy, eradication of cancer cells through activation of the innate immune system has achieved inspiring results, whereas only a handful of patients show a durable response. The tumor-suppressive environment has been investigated with respect to playing a vital role in cancer relapse. In this review, we uncover the heterogeneity of the origin of TAMs, as well as the functions of TAMs in tumor progression associated with intricate regulatory networks in the tumor microenvironment, aiming to inspire therapeutic insight for tumor immunotherapy.
肿瘤相关巨噬细胞（TAMs）是肿瘤微环境的重要组成部分，参与癌症的进展和转移。它们在正常和恶性组织中的血管生成和免疫抑制中密切相关，并且具有促纤维化活性。随着免疫疗法的发展，通过激活先天免疫系统来消除癌细胞已经取得了令人鼓舞的结果，但是只有少数患者表现出持久的反应。人们已经研究了肿瘤抑制环境在癌症复发中所起的重要作用。在这篇综述中，我们揭示了 TAMs 起源的异质性，以及 TAMs 在肿瘤进展中的功能，以及肿瘤微环境中复杂的调控网络，旨在为肿瘤免疫治疗提供治疗思路。
