Parr N J, Grime S, Brownless S, Critchley M, Baxter J N, Mackie C R
University Department of Surgery, Royal Liverpool Hospital, UK.
Br J Surg. 1988 Mar;75(3):279-82. doi: 10.1002/bjs.1800750330.
Gastric emptying of liquid was studied in 10 normal volunteers and in 27 patients previously treated with truncal vagotomy and drainage. Thirteen of the twenty-seven patients complained of persistent postvagotomy diarrhoea. For each study 300 ml 15 per cent dextrose, labelled with 99mTc-diethylene triamine penta-acetic acid (DTPA), was ingested at a standard rate by subjects who sat facing a gamma camera. Imaging proceeded for 30 min. Gastric area activity curves were corrected for emptying of the test meal during ingestion, and for movement using a new image alignment technique. Gastric emptying at 15 min was 10 +/- 2.6 per cent (mean +/- s.e.m.) in healthy volunteers, 48 +/- 7.3 per cent in patients without diarrhoea, and 84 +/- 2.3 per cent in those with diarrhoea (P less than 0.001, ANOVA). Gastric emptying from 15 min onwards was slower than normal in both patient groups (P less than 0.001). These results show that initial gastric emptying is rapid following truncal vagotomy and drainage, and this change is greater in patients with postvagotomy diarrhoea. No patient with diarrhoea had normal initial gastric emptying.
对10名正常志愿者和27名曾接受迷走神经干切断术及引流术治疗的患者进行了液体胃排空研究。27名患者中有13名抱怨迷走神经切断术后持续腹泻。每项研究中，受试者面对γ相机以标准速率摄入300毫升含99m锝-二乙三胺五乙酸（DTPA）的15%葡萄糖溶液。成像持续30分钟。胃区活性曲线针对摄入期间试餐的排空以及使用一种新的图像对齐技术进行的移动进行了校正。健康志愿者15分钟时的胃排空率为10±2.6%（平均值±标准误），无腹泻的患者为48±7.3%，腹泻患者为84±2.3%（方差分析，P<0.001）。两组患者15分钟后胃排空均比正常慢（P<0.001）。这些结果表明，迷走神经干切断术及引流术后初始胃排空迅速，且这种变化在迷走神经切断术后腹泻患者中更大。没有腹泻患者的初始胃排空正常。
