Department of Otorhinolaryngology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi Meghe, Wardha, Maharashtra, India - 442004.
Department of Otorhinolaryngology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi Meghe, Wardha, Maharashtra, India - 442004.
Am J Otolaryngol. 2021 May-Jun;42(3):102892. doi: 10.1016/j.amjoto.2020.102892. Epub 2021 Jan 16.
To study the outcome of fluticasone nasal sprays in smell disorders and triamcinolone paste in taste dysfunction in a population of laboratory-confirmed SARS-CoV-2 patients as the test group. The control group will not be given any intervention and only monitoring of these symptoms will be done to compare the recovery time.
This prospective interventional study was conducted from June to Nov 2020 at, Datta Meghe University during the COVID-19 outbreak. The 120 enrolled patients were tested at days 1 and 5 after proven infection by RT-PCR test.
The mean age for all cases is 50.88 ± 15.93 years, whereas for the controls mean age is 51.2 ± 14.89. 2. Among cases 45 (75%) were males and 15 (25%) were females, among controls 43 (71.66%) were males and 17 (28.33%) were females. Among the case group, after the use of fluticasone spray in the nose and triamcinolone paste in the mouth there was a statistically significant improvement in recognizing all the odours and taste on day 5 compared to day 1. On comparing the smell and taste of cases and control group, either there is no improvement or worsening in smell or taste on day 5 in the control group.
The use of fluticasone nasal spray and triamcinolone paste had immensely influenced the basic senses such as smell and taste. Our study showed that olfactory and taste function significantly improved in patients with COVID-19. For all anosmia and dysgeusia cases who received fluticasone nasal spray and triamcinolone medications the recovery of smell senses and the taste was within a week.
研究了在一组经实验室确认的 SARS-CoV-2 患者中，使用氟替卡松鼻喷雾剂治疗嗅觉障碍和曲安奈德糊剂治疗味觉障碍的效果，将该组患者作为试验组。对照组不给予任何干预，仅对这些症状进行监测，以比较恢复时间。
这项前瞻性干预研究于 2020 年 6 月至 11 月在 COVID-19 疫情期间在 Datta Meghe 大学进行。对经 RT-PCR 检测证实感染后第 1 天和第 5 天的 120 名入组患者进行了测试。
所有病例的平均年龄为 50.88±15.93 岁，而对照组的平均年龄为 51.2±14.89 岁。2. 在病例组中，45 例（75%）为男性，15 例（25%）为女性，在对照组中，43 例（71.66%）为男性，17 例（28.33%）为女性。在病例组中，在鼻腔使用氟替卡松喷雾和口腔使用曲安奈德糊剂后，与第 1 天相比，第 5 天识别所有气味和味觉的能力有显著改善。在比较病例组和对照组的嗅觉和味觉时，对照组第 5 天的嗅觉或味觉既没有改善，也没有恶化。
使用氟替卡松鼻喷雾剂和曲安奈德糊剂对嗅觉和味觉等基本感觉有很大影响。我们的研究表明，COVID-19 患者的嗅觉和味觉功能显著改善。对于所有接受氟替卡松鼻喷雾剂和曲安奈德治疗的嗅觉丧失和味觉障碍患者，嗅觉和味觉的恢复在一周内。
