UCL Huntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
UCL Huntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Parkinsonism Relat Disord. 2021 Feb;83:93-104. doi: 10.1016/j.parkreldis.2021.01.006. Epub 2021 Jan 12.
In chronic neurological conditions, wearable/portable devices have potential as innovative tools to detect subtle early disease manifestations and disease fluctuations for the purpose of clinical diagnosis, care and therapeutic development. Huntington's disease (HD) has a unique combination of motor and non-motor features which, combined with recent and anticipated therapeutic progress, gives great potential for such devices to prove useful. The present work aims to provide a comprehensive account of the use of wearable/portable devices in HD and of what they have contributed so far. We conducted a systematic review searching MEDLINE, Embase, and IEEE Xplore. Thirty references were identified. Our results revealed large variability in the types of sensors used, study design, and the measured outcomes. Digital technologies show considerable promise for therapeutic research and clinical management of HD. However, more studies with standardized devices and harmonized protocols are needed to optimize the potential applicability of wearable/portable devices in HD.
在慢性神经疾病中，可穿戴/便携式设备具有作为创新工具的潜力，可以检测细微的早期疾病表现和疾病波动，以用于临床诊断、护理和治疗开发。亨廷顿病（HD）具有运动和非运动特征的独特组合，结合最近和预期的治疗进展，为这些设备的实用性提供了很大的潜力。本工作旨在全面介绍可穿戴/便携式设备在 HD 中的应用，以及它们迄今为止的贡献。我们进行了系统的文献检索，检索了 MEDLINE、Embase 和 IEEE Xplore。确定了 30 篇参考文献。我们的结果显示，所使用的传感器类型、研究设计和测量结果存在很大的差异。数字技术在 HD 的治疗研究和临床管理方面显示出巨大的潜力。然而，需要更多具有标准化设备和协调一致方案的研究，以优化可穿戴/便携式设备在 HD 中的潜在适用性。
