Smith D A, Barker I K, Allen O B
Department of Pathology, Ontario Veterinary College, University of Guelph.
Can J Vet Res. 1988 Jan;52(1):120-8.
The effects of ambient temperature (13.5 degrees C, 21 degrees C, 30 degrees C) and type of wound on healing of skin wounds were evaluated in common garter snakes (Thamnophis sirtalis). Linear unsutured incisions and circular excisional wounds were evaluated grossly and microscopically in three snakes held at each temperature at each of two, five and ten days after surgery. Linear sutured and unsutured incisions and circular and square excisional wounds were similarly evaluated three and six weeks after wound production in groups of six snakes held at each temperature. The rates of stabilization of wound margins, scab formation, migration and maturation of the regenerating epithelium, resolution of dermal inflammation, and fibroplasia varied directly with temperature. The inflammatory reaction to wounding was similar in character and intensity in snakes held at all three temperatures two days after surgery. Unsutured linear incisions, compared to sutured incisions, tended to have more rapid epithelial maturation and a less intense inflammatory response. Healing of square and circular excisional wounds was similar; contraction of round wounds was slightly more irregular and, at a few observations, dermal maturation was slower and inflammation more widespread. It was concluded that healing of skin wounds can be accelerated by holding reptiles at the upper end of their voluntary temperature range. Wounds, if possible, should be created along the axis of lines of skin tension. Suturing small incisional wounds may not be advantageous.
研究人员在东部束带蛇（Thamnophis sirtalis）身上评估了环境温度（13.5摄氏度、21摄氏度、30摄氏度）和伤口类型对皮肤伤口愈合的影响。在术后第2天、第5天和第10天，将每组3条蛇分别置于上述每个温度环境下，对线性未缝合切口和圆形切除伤口进行大体和显微镜观察。在伤口形成后第3周和第6周，将每组6条蛇分别置于每个温度环境下，对线性缝合和未缝合切口以及圆形和方形切除伤口进行类似评估。伤口边缘的稳定速率、结痂形成、再生上皮的迁移和成熟、真皮炎症的消退以及纤维增生均与温度呈正相关。术后2天，在所有三个温度环境下的蛇对伤口的炎症反应在性质和强度上相似。与缝合切口相比，未缝合的线性切口往往上皮成熟更快，炎症反应更轻。方形和圆形切除伤口的愈合情况相似；圆形伤口的收缩略显不规则，在少数观察中，真皮成熟较慢，炎症更广泛。研究得出结论，将爬行动物置于其自主温度范围的上限可以加速皮肤伤口的愈合。如有可能，伤口应沿皮肤张力线的轴线制造。缝合小切口伤口可能并无益处。
