Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China.
Department of Pharmacy, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, 518034, China.
Biomed Pharmacother. 2021 May;137:111244. doi: 10.1016/j.biopha.2021.111244. Epub 2021 Jan 22.
Depression is the second most common disease burden worldwide that threatens human health; however, mechanisms underlying the development of depression remain unclear. A family of non-coding RNAs, circular RNAs (circRNAs), has been shown to play a critical role in the development of depression by competitively binding to certain microRNAs (miRNA) and regulating the expression of target genes. Behavioral symptoms of depression may be ameliorated by knockdown or overexpression of depression-associated circRNAs. In this review, we summarized important functions of circRNAs and analyzed the most recent findings regarding the expression and biological function of circRNAs in depression. We discussed novel circRNA-based strategies to illuminate potential therapeutic targets that may aid in the development of new treatments for depression.
抑郁症是全球第二大致病负担，威胁人类健康；然而，抑郁症发展的机制仍不清楚。一类非编码 RNA，circRNAs，通过竞争性结合某些 microRNAs（miRNA）和调节靶基因的表达，在抑郁症的发展中发挥关键作用。通过敲低或过表达与抑郁症相关的 circRNAs 可以改善抑郁症的行为症状。在这篇综述中，我们总结了 circRNAs 的重要功能，并分析了最近关于 circRNAs 在抑郁症中的表达和生物学功能的研究结果。我们讨论了基于新型 circRNA 的策略，以阐明潜在的治疗靶点，这可能有助于开发新的抑郁症治疗方法。
