Zhang S, Huang J H, Chen P L, Li C H
Central Research Laboratory, Chinese PLA General Hospital, Beijing.
Cancer Genet Cytogenet. 1988 Apr;31(2):157-63. doi: 10.1016/0165-4608(88)90211-7.
The effect of different cytostatic chemotherapeutic drugs on the frequency of sister chromatid exchanges and growth kinetics of the bone marrow cells in normal adults was studied by means of an in vitro bromodeoxyuridine chromosome labeling method. Cytosine arabinoside, harringtonine, methotrexate, vincristine, and 6-mercaptopurine were tested. Three of these agents induced significantly high frequency of sister chromatid exchange (p less than 0.01 or p less than 0.05). The sister chromatid exchange frequency induced by cytosine arabinoside and that induced by 6-mercaptopurine were higher than those of the control group. The increased frequency of sister chromatid exchange predominated in C and A group chromosomes. At the concentration adopted by the authors, the growth kinetics were little influenced by these drugs.
采用体外溴脱氧尿苷染色体标记法，研究了不同的细胞抑制性化疗药物对正常成年人骨髓细胞姐妹染色单体交换频率和生长动力学的影响。对阿糖胞苷、三尖杉酯碱、甲氨蝶呤、长春新碱和6-巯基嘌呤进行了测试。其中三种药物诱导出显著高频率的姐妹染色单体交换（p小于0.01或p小于0.05）。阿糖胞苷和6-巯基嘌呤诱导的姐妹染色单体交换频率高于对照组。姐妹染色单体交换频率的增加在C组和A组染色体中占主导。在所采用的浓度下，这些药物对生长动力学影响很小。
