Janardhana V, Propert D N, Cooper I, Wolf M, Garson O M, Hopper J L, Dickson B J
Department of Applied Biology, Royal Melbourne Institute of Technology, Australia.
Cancer Genet Cytogenet. 1988 Apr;31(2):179-86. doi: 10.1016/0165-4608(88)90215-4.
Immunoglobulin allotypes of the Gm and Km systems have been compared in patients with various forms of hematologic malignancies and healthy controls of the same ethnographic background. These comparisons found an increased frequency of the haplotype Gm and a decreased frequency of Gm in patients with Hodgkin's disease; a decreased frequency of Gm in diffuse, large-cell lymphoma patients; a decreased frequency of Gm and an increased frequency of Gm in acute myeloid leukemia patients; a decreased frequency of Gm in chronic myeloid leukemia patients, and an increased frequency of the phenotype Km(1+) in chronic lymphocytic leukemia patients. These results support previous suggestions of the involvement of immunoglobulin allotypes in the susceptibility to some forms of human hematologic malignancy.
在具有相同人种学背景的各种血液系统恶性肿瘤患者和健康对照中，对Gm和Km系统的免疫球蛋白同种异型进行了比较。这些比较发现，霍奇金病患者中Gm单倍型频率增加而Gm频率降低；弥漫性大细胞淋巴瘤患者中Gm频率降低；急性髓细胞白血病患者中Gm频率降低而Gm频率增加；慢性髓细胞白血病患者中Gm频率降低，慢性淋巴细胞白血病患者中Km(1+)表型频率增加。这些结果支持了先前关于免疫球蛋白同种异型参与某些人类血液系统恶性肿瘤易感性的观点。
