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丹麦和瑞典 Falck 紧急和非紧急医疗保健工作者中 SARS-CoV-2 IgG/IgM 抗体的流行情况。

Prevalence of SARS-CoV-2 IgG/IgM Antibodies among Danish and Swedish Falck Emergency and Non-Emergency Healthcare Workers.

机构信息

Department of Global Business Quality Management, Falck, Sydhavnsgade 18, 2450 Copenhagen, Denmark.

Center for Clinical Research and Prevention, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark.

出版信息

Int J Environ Res Public Health. 2021 Jan 21;18(3):923. doi: 10.3390/ijerph18030923.

Abstract

BACKGROUND

Knowledge about the COVID-19 outbreak is still sparse, especially in a cross-national setting. COVID-19 is caused by a SARS-CoV-2 infection. The aim of the study is to contribute to the surveillance of the pandemic by bringing new knowledge about SARS-CoV-2 seropositivity among healthcare workers. It seeks to evaluate whether certain job functions are associated with a higher risk of being infected and to clarify if such association is mediated by the number of individuals that employees meet during a workday. In addition, we investigate regional and national differences in seroprevalence.

METHODS

This research involved a bi-national prospective observational cohort study including 3272 adults employed at Falck in Sweden and Denmark. Participants were tested for SARS-CoV-2 antibodies every second week for a period of 8 weeks from 22 June 2020 until 10 August 2020. Descriptive statistics as well as multivariable logistic regression analyses were applied.

RESULTS

Of the 3272 Falck employees participating in this study, 159 (4.9%) tested positive for SARS-CoV-2 antibodies. The seroprevalence was lower among Danish Falck employees than among those from Sweden (2.8% in Denmark and 8.3% in Sweden). We also found that the number of customer or patient contacts during a workday was the most prominent predictor for seropositivity and that ambulance staff was the most vulnerable staff group.

CONCLUSION

Our study presents geographical variations in seroprevalence within the Falck organization and shows evidence that social interaction is one of the biggest risk factors for becoming infected with SARS-CoV-2.

摘要

背景

关于 COVID-19 疫情的知识仍然很匮乏,特别是在跨国环境下。COVID-19 是由 SARS-CoV-2 感染引起的。本研究旨在通过提供有关医护人员中 SARS-CoV-2 血清阳性率的新知识,为疫情监测做出贡献。本研究旨在评估某些工作职能是否与更高的感染风险相关,并阐明这种关联是否通过员工在工作日期间接触的人数来介导。此外,我们还研究了血清阳性率的地区和国家差异。

方法

这是一项涉及瑞典和丹麦 Falck 公司的 3272 名成年人的双国籍前瞻性观察队列研究。参与者从 2020 年 6 月 22 日至 2020 年 8 月 10 日期间,每两周接受一次 SARS-CoV-2 抗体检测,共进行了 8 周。采用描述性统计和多变量逻辑回归分析。

结果

在参与本研究的 3272 名 Falck 员工中,有 159 人(4.9%)检测出 SARS-CoV-2 抗体呈阳性。丹麦 Falck 员工的血清阳性率低于瑞典员工(丹麦为 2.8%,瑞典为 8.3%)。我们还发现,工作日期间与客户或患者的接触次数是血清阳性的最显著预测因素,而救护车工作人员是最脆弱的员工群体。

结论

我们的研究显示 Falck 组织内血清阳性率存在地域差异,并表明社交互动是感染 SARS-CoV-2 的最大风险因素之一。

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