Lim See Meng, Choo Jocelyn M, Li Hui, O'Rielly Rebecca, Carragher John, Rogers Geraint B, Searle Iain, Robertson Sarah A, Page Amanda J, Muhlhausler Beverly
School of Agriculture, Food and Wine, The University of Adelaide, Glen Osmond 5064, Australia.
South Australian Health and Medical Research Institute, Adelaide 5000, Australia.
Foods. 2021 Jan 21;10(2):220. doi: 10.3390/foods10020220.
High amylose wheat (HAW) contains more resistant starch than standard amylose wheat (SAW) and may have beneficial effects on gastrointestinal health. However, it is currently unclear whether these effects differ according to the level of HAW included in the diet or between males and females. Male and female C57BL/6 mice ( = 8/group/sex) were fed SAW65 (65% SAW; control), HAW35 (35% HAW), HAW50 (50% HAW) or HAW65 (65% HAW) diet for eight weeks. Female but not male, mice consuming any amount of HAW exhibited accelerated gastric emptying compared to SAW65 group. In both sexes, relative colon weights were higher in the HAW65 group compared to SAW65 group and in females, relative weights of the small intestine and cecum were also higher in the HAW65 group. In females only, colonic expression of and mRNAs were higher in the HAW65 group compared to HAW35 and HAW50 groups. In both sexes, mice consuming higher amounts of HAW (HAW50 or HAW65) had increased fecal bacterial load and relative abundance of Bacteroidetes phylum and reduced relative abundance of Firmicutes compared to SAW65 group. These data are consistent with a beneficial impact of HAW on gastrointestinal health and indicate dose-dependent and sex-specific effects of HAW consumption.
高直链淀粉小麦（HAW）比标准直链淀粉小麦（SAW）含有更多的抗性淀粉，可能对胃肠道健康有益。然而，目前尚不清楚这些影响是否因饮食中HAW的含量水平不同或男女之间存在差异。将雄性和雌性C57BL/6小鼠（每组/性别 = 8只）喂食SAW65（65% SAW；对照）、HAW35（35% HAW）、HAW50（50% HAW）或HAW65（65% HAW）饮食八周。与SAW65组相比，食用任何量HAW的雌性小鼠（而非雄性小鼠）胃排空加速。在两性中，与SAW65组相比，HAW65组的相对结肠重量更高，并且在雌性中，HAW65组的小肠和盲肠相对重量也更高。仅在雌性中，与HAW35组和HAW50组相比，HAW65组中 和 mRNA的结肠表达更高。在两性中，与SAW65组相比，食用较高量HAW（HAW50或HAW65）的小鼠粪便细菌负荷增加，拟杆菌门相对丰度增加，厚壁菌门相对丰度降低。这些数据与HAW对胃肠道健康的有益影响一致，并表明食用HAW具有剂量依赖性和性别特异性效应。
