Department of Respiratory and Critical Care Medicine, Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Respiratory Diseases, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Department of Respiratory and Critical Care Medicine, Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute of Respiratory Diseases, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Med Clin (Barc). 2022 Jan 21;158(2):70-72. doi: 10.1016/j.medcli.2020.10.017. Epub 2021 Jan 23.
The aim of this study was to assess the diagnostic value of several markers for tuberculosis pleural effusion (TPE) using the combined analysis of Lactate dehydrogenase (LDH), Carbohydrate antigen 125 (CA125), Cytokeratin-19 fragment (CYFRA21-1).
From January to December in 2018, a total of 37 patients with pleural effusion (22 cases of transudative pleural effusion, 15 cases of tuberculosis pleural effusion and 22 cases of Transudative pleural effusion who were hospitalized in our hospital were reviewed. Receiver operating characteristic (ROC) curves and logistic regression equations was used to evaluate the diagnostic efficiency of each marker.
The levels of LDH and CYFRA21-1 of tuberculosis pleural effusions were obviously higher than those of transudative pleural effusion with statistically significant difference (<0.05). The areas under the ROC curve of LDH, CA125 and CYFRA21-1 were 0.92, 0.344 and 0.656, respectively. The diagnostic sensitivity of LDH, CA125 and CYFRA21-1 were 100%, 13.3%, 73.3%, respectively. The combined detection of LDH, CA125 and CYFRA21-1 were higher than those of any other combinations of the indexes.
The study showed a high diagnostic sensitivity and specificity of combined speculation of LDH, ADA and CYFRA21-1 in Tuberculosis pleural effusion.
本研究旨在通过对乳酸脱氢酶（LDH）、糖抗原 125（CA125）、细胞角蛋白 19 片段（CYFRA21-1）的联合分析，评估几种标志物对结核性胸腔积液（TPE）的诊断价值。
2018 年 1 月至 12 月，回顾性分析我院收治的 37 例胸腔积液患者（22 例渗出性胸腔积液，15 例结核性胸腔积液）。采用受试者工作特征（ROC）曲线和逻辑回归方程评估各标志物的诊断效率。
结核性胸腔积液组 LDH 和 CYFRA21-1 水平明显高于渗出性胸腔积液组，差异有统计学意义（<0.05）。LDH、CA125 和 CYFRA21-1 的 ROC 曲线下面积分别为 0.92、0.344 和 0.656。LDH、CA125 和 CYFRA21-1 的诊断敏感度分别为 100%、13.3%和 73.3%。LDH、CA125 和 CYFRA21-1 的联合检测敏感度均高于任何其他指标组合。
本研究表明 LDH、ADA 和 CYFRA21-1 联合推测对结核性胸腔积液具有较高的诊断灵敏度和特异性。
