Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
University of Edinburgh Centre for Inflammation Research, Queens Medical Research Institute, Edinburgh, EH16 4TJ, UK.
Mucosal Immunol. 2021 May;14(3):542-543. doi: 10.1038/s41385-020-00369-0. Epub 2021 Jan 25.
A recent paper in proposes a new role for macrophages in the distal colonic mucosa, namely the generation of balloon-like processes (BLPs) that sample luminal contents and protect epithelial cells from the toxic effects of fungal metabolites absorbed during this process. Here Allan Mowat and Calum Bain discuss the implications of these novel findings for intestinal physiology and macrophage biology, highlighting how they extend our understanding of how tissue resident macrophages can adapt precisely to the physiological needs of individual anatomical niches. [Image: see text]
最近发表在[期刊名称]上的一篇论文提出了巨噬细胞在远端结肠黏膜中的新作用，即生成气球样突起（BLPs），这些突起可以采集腔内容物，并保护上皮细胞免受在此过程中吸收的真菌代谢物的毒性影响。在这里，Allan Mowat 和 Calum Bain 讨论了这些新发现对肠道生理学和巨噬细胞生物学的意义，强调了它们如何扩展我们对组织驻留巨噬细胞如何能够精确适应个体解剖龛位的生理需求的理解。[图片：见正文]
