Rajput Swati, Paliwal Deepanshu, Naithani Manisha, Kothari Aashish, Meena Kiran, Rana Satyavati
Department of Biochemistry, AIIMS Rishikesh, Uttarakhand, 249203 India.
Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand India.
Indian J Clin Biochem. 2021 Jul;36(3):266-277. doi: 10.1007/s12291-020-00948-9. Epub 2021 Jan 21.
Currently, world is facing a global outbreak causing a pandemic threat known as COVID-19. This infectious disease is triggered by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Gut microbiota harbours multi species community with a strong impact on host immune homeostasis. However, our knowledge about this gut microbiota and its symbiotic relationship with immune activation in association with SARS-CoV-2 is limited. Unbalanced bacterial flora with too many opportunistic infections can shift immune system towards a cascade of inflammatory responses leading to multi organ damage. This review will highlight immune-regulation via various mechanisms in SARS-CoV-2 infection. Diet has an unbelievable influence on gut microbiome that allows a new state of homeostasis to be reached through timing, frequency and duration of intake. This review article focuses on gut, lung microbiota and immunomodulation with specific attention on immune activation by gut microbiota.
当前，世界正面临一场全球性疫情，引发了一种名为COVID-19的大流行威胁。这种传染病是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发的。肠道微生物群包含多种菌群，对宿主免疫稳态有重大影响。然而，我们对这种肠道微生物群及其与SARS-CoV-2相关的免疫激活的共生关系的了解有限。细菌菌群失衡，机会性感染过多，会使免疫系统转向一系列炎症反应，导致多器官损伤。本综述将重点介绍SARS-CoV-2感染中通过各种机制进行的免疫调节。饮食对肠道微生物群有着不可思议的影响，通过摄入的时间、频率和持续时间可以达到一种新的稳态。这篇综述文章重点关注肠道、肺部微生物群以及免疫调节，特别关注肠道微生物群引起的免疫激活。
