Firer M A, Hosking C S, Hill D J
Royal Children's Hospital, Melbourne, Australia.
Clin Allergy. 1988 Jan;18(1):53-61. doi: 10.1111/j.1365-2222.1988.tb02843.x.
In order to test the hypothesis that rotavirus infection leads to IgE hypersensitivity to cows' milk, evidence of past rotavirus infection, as reflected by the presence of antibodies, was sought in two groups of children with cows' milk allergy. The groups were defined according to the time to react to milk challenge. In group I there were fifteen children with an adverse reaction within 40 min of milk challenge. The twenty-one children in group II had gastrointestinal reactions between 1 hr and 24 hr after milk challenge. The results showed a higher incidence of antibodies to rotavirus in group II than group I (P less than 0.05). Although group I patients had significantly higher levels of total and milk-specific IgE antibodies to cows' milk than those in group II, both patient groups had lower levels of serum IgG, IgA and IgM than a control population. No association between the presence of rotavirus antibodies and IgE hypersensitivity to cows' milk was found. However, an association between non-IgE milk enteropathy and previous rotavirus antibodies was demonstrated.
为了验证轮状病毒感染会导致对牛奶产生IgE超敏反应这一假说，在两组牛奶过敏儿童中探寻了过去轮状病毒感染的证据，该证据通过抗体的存在来体现。根据对牛奶激发试验的反应时间对两组进行了定义。第一组有15名儿童在牛奶激发试验后40分钟内出现不良反应。第二组的21名儿童在牛奶激发试验后1小时至24小时之间出现胃肠道反应。结果显示，第二组中抗轮状病毒抗体的发生率高于第一组（P小于0.05）。虽然第一组患者针对牛奶的总IgE抗体和牛奶特异性IgE抗体水平显著高于第二组，但两组患者的血清IgG、IgA和IgM水平均低于对照组人群。未发现轮状病毒抗体的存在与对牛奶的IgE超敏反应之间存在关联。然而，非IgE牛奶肠病与既往轮状病毒抗体之间存在关联。
