Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Hacettepe University, 06100, Sihhiye, Ankara, Turkey.
Faculty of Medicine, Department of Medical Microbiology, Hacettepe University, Ankara, Turkey.
Eur J Clin Microbiol Infect Dis. 2021 Jul;40(7):1539-1545. doi: 10.1007/s10096-020-04147-5. Epub 2021 Jan 26.
Fungemia caused by uncommon Candida species (UCS) (other than C.albicans, C.glabrata, C.parapsilosis, C.tropicalis, C.krusei) is a rare but emerging threat with their potential to exhibit reduced susceptibility or resistance to antifungal agents. We identified 25 patients with UCS fungemia (9 C.kefyr, 8 C.lusitaniae, 4 C.dubliniensis, 2 C.guilliermondii, 1 C.pelliculosa, 1 C.rugosa) through January 2011 and August 2018. Echinocandins were the most common administered agents, followed by fluconazole. Overall mortality was 44%. Echinocandins and voriconazole showed sufficient activity against all tested isolates. High fluconazole MICs among C.guilliermondii, C.pelliculosa, and C.rugosa were determined. MIC value of C.pelliculosa was above the epidemiological cut-off proposed for fluconazole.
由不常见的念珠菌物种（UCS）引起的菌血症（除 C.albicans、C.glabrata、C.parapsilosis、C.tropicalis、C.krusei 外）是一种罕见但正在出现的威胁，这些真菌可能表现出对抗真菌药物的敏感性降低或耐药性。我们通过 2011 年 1 月至 2018 年 8 月期间确定了 25 例 UCS 菌血症患者（9 例 C.kefyr、8 例 C.lusitaniae、4 例 C.dubliniensis、2 例 C.guilliermondii、1 例 C.pelliculosa、1 例 C.rugosa）。棘白菌素类是最常用的给药药物，其次是氟康唑。总死亡率为 44%。所有测试的分离株对棘白菌素类和伏立康唑均显示出足够的活性。在 C.guilliermondii、C.pelliculosa 和 C.rugosa 中确定了高氟康唑 MIC 值。C.pelliculosa 的 MIC 值高于氟康唑的流行病学截止值。
