Yavuz Berire, Turhan Özge, Özyurt Özlem Koyuncu, Çetinkaya Özgül, Ayaz Çağlayan Merve, Özhak Betil, Mamıkoğlu Latife
Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Department of Medical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
BMC Microbiol. 2025 Jul 2;25(1):385. doi: 10.1186/s12866-025-04016-1.
With advancements in healthcare services, there has been an increase in the population of immunosuppressed patients and the frequency of opportunistic pathogens including rare yeasts (RY). We aimed to provide data on the distribution of RY causing invasive infections and their antifungal susceptibility profiles. In this retrospective study, the distribution of RYs obtained between January 2015 and January 2023 examined. Antifungal susceptibility analyses of the isolates conducted using the broth microdilution method following European Committee on Antimicrobial Susceptibility Testing (EUCAST) recommendations. The patients' demographics, predisposing factors and outcomes were investigated.
A total of 15 species were identified from 56 clinical samples, including Clavispora lusitaniae, Kluyveromyces marxianus, Magnusiomyces capitatus, Wickerhamomyces anomalus, Meyerozyma guilliermondii, Magnusiomyces clavatus, Candida dubliniensis, Rhodotorula mucilaginosa, Cyberlindnera jadinii, Pichia inconspicua, Candida auris, Yarrowia lipolytica, Trichosporon asahii, Wickerhamiella pararugosa and Saccharomyces cerevisiae. Observed highly heterogenous antifungal susceptibility results depending on the species. Admission to the intensive care unit (ICU), being 65 years or older, and neutropenia increased mortality. Fourteen-day and 30-day mortality rates were 27.8% and 35.2%, respectively.
The variability of RY encountered in various centers and differences in antifungal susceptibility profiles warrant further research on this topic, both regionally and globally.
随着医疗服务的进步，免疫抑制患者的数量以及包括罕见酵母（RY）在内的机会性病原体的感染频率均有所增加。我们旨在提供有关引起侵袭性感染的罕见酵母的分布及其抗真菌药敏谱的数据。在这项回顾性研究中，我们检查了2015年1月至2023年1月期间分离出的罕见酵母的分布情况。按照欧洲抗菌药物敏感性测试委员会（EUCAST）的建议，采用肉汤微量稀释法对分离株进行抗真菌药敏分析。我们还调查了患者的人口统计学特征、易感因素和预后情况。
从56份临床样本中共鉴定出15个菌种，包括葡萄牙棒孢酵母、马克斯克鲁维酵母、头状麦角酵母、异常威克汉姆酵母、季也蒙梅耶酵母、棒状麦角酵母、都柏林假丝酵母、粘红酵母、嘉丁 Cyberlindnera jadinii、 inconspicua毕赤酵母、耳念珠菌、解脂耶氏酵母、阿萨希毛孢子菌、副粗糙威克汉姆酵母和酿酒酵母。观察到不同菌种的抗真菌药敏结果差异很大。入住重症监护病房（ICU）、年龄在65岁及以上以及中性粒细胞减少会增加死亡率。14天和30天死亡率分别为27.8%和35.2%。
不同中心遇到的罕见酵母的变异性以及抗真菌药敏谱的差异，需要在区域和全球范围内对该主题进行进一步研究。
