Department of Hand and foot surgery, The affiliated hospital of QingDao university, ShangDong, China.
Department of Anesthesiology, Bonn University, Bonn, Germany.
Clin Exp Pharmacol Physiol. 2021 Apr;48(4):445-454. doi: 10.1111/1440-1681.13466. Epub 2021 Jan 25.
Dequalinium chloride has been known as one kind of antibiotic that displays a broad antimicrobial spectrum and has been clinically proven to be very safe. In recent years, studies have shown that dequalinium chloride can inhibit the growth of malignant tumours, and reports were mainly used for solid tumours. Glioblastoma is the most common malignant neuroepithelial tumour of the central nervous system in adults, and the prognosis of glioblastoma is poor as it has a high resistance to apoptosis. This review summarizes the current understanding of dequalinium chloride-induced cancer cell apoptosis and its potential role in glioblastoma resistance and progression. Particularly, we focus on dequalinium chloride as it exerts a wide range of anti-cancer activity through its ability to target and accumulate in the mitochondria, and it effectively inhibits the growth of glioblastoma cells in vitro and vivo. Dequalinium chloride is an inhibitor of XIAP and can also act as a mitochondrial targeting agent, which gives it an interesting perspective regarding recent advances in the treatment of malignant glioma.
盐酸苯扎氯铵作为一种具有广谱抗菌活性的抗生素，已被临床证实非常安全。近年来的研究表明，盐酸苯扎氯铵能够抑制恶性肿瘤的生长，相关报道主要集中在实体瘤方面。胶质母细胞瘤是成人中枢神经系统中最常见的恶性神经上皮肿瘤，由于对细胞凋亡具有较高的抗性，其预后较差。本综述总结了目前对盐酸苯扎氯铵诱导癌细胞凋亡及其在胶质母细胞瘤耐药性和进展中潜在作用的认识。特别是，我们重点关注盐酸苯扎氯铵，因为它通过靶向和积累在线粒体中发挥广泛的抗癌活性，并且能够有效抑制体外和体内胶质母细胞瘤细胞的生长。盐酸苯扎氯铵是 XIAP 的抑制剂，也可以作为线粒体靶向剂，这为恶性神经胶质瘤的治疗提供了一个有趣的视角。
