纳米粒子的 Mn-DNA 配位用于高效化学动力学治疗。
Mn-DNA coordination of nanoparticles for efficient chemodynamic therapy.
机构信息
Department of Materials Science and Engineering, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, P. R. China.
Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China.
出版信息
Chem Commun (Camb). 2021 Feb 19;57(14):1734-1737. doi: 10.1039/d0cc08191d.
A kind of nanoparticle is developed for highly efficient chemodynamic therapy that only relies on the endogenous H2O2 of cancer cells. For this nanoparticle, high-molecular-weight DNA is used as the biocompatible carrier to load abundant Mn2+ ions. Therefore, the resultant Mn-DNA coordination nanoparticles can efficiently deliver and sensitively release Mn2+ in cancer cells, resulting in high toxicity through the Fenton-like reaction.
研发了一种纳米颗粒用于高效的化学动力学治疗，该治疗仅依赖于癌细胞内源性的 H2O2。对于这种纳米颗粒，高分子量 DNA 被用作生物相容性载体来负载丰富的 Mn2+离子。因此，所得的 Mn-DNA 配位纳米颗粒可以在癌细胞中有效地传递和敏感地释放 Mn2+，通过类 Fenton 反应产生高毒性。
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