文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

金属离子与天然产物的相互作用：天然产物-配位金属离子在肿瘤诊断和治疗中的应用。

An encounter between metal ions and natural products: natural products-coordinated metal ions for the diagnosis and treatment of tumors.

机构信息

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.

State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

出版信息

J Nanobiotechnology. 2024 Nov 21;22(1):726. doi: 10.1186/s12951-024-02981-9.

DOI:10.1186/s12951-024-02981-9
PMID:39574109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11580416/
Abstract

Natural products-coordinated metal ions to form the nanomedicines are in the spotlight for cancer therapy. Some natural products could be coordinated with metal ions forming nanomedicines via simple and green environmental self-assembly, which not only improved the bioavailability of natural products, but also conferred multiple therapeutic modalities and multimodal imaging. On the one hand, in the weak acidity, glutathione (GSH) and hydrogen peroxide (HO) overexpression of tumor microenvironment (TME), such carrier-free nanomedicines could be further enhanced the therapeutic effect via optimizing the species of metal ions. On the other hand, nanomedicines could exert the precise treatment of tumor under the guidance of multiple imaging. Hence, this review summarized the research progress in recent years on the application of natural product-coordinated metal ions in cancer therapy. In addition, the prospects and challenges for the application of natural product-coordinated metal ions were discussed, especially how to improve targeting ability and stability and assess the safety of metal ions, so as to facilitate the clinical translation and application of natural product-coordinated metal ions nanomedicines.

摘要

天然产物与金属离子配位形成的纳米药物是癌症治疗的焦点。一些天然产物可以通过简单、绿色的环境自组装与金属离子配位形成纳米药物，不仅提高了天然产物的生物利用度，而且赋予了多种治疗模式和多模态成像。一方面，在肿瘤微环境（TME）的弱酸性、谷胱甘肽（GSH）和过氧化氢（HO）过表达的情况下，这种无载体的纳米药物可以通过优化金属离子的种类进一步增强治疗效果。另一方面，纳米药物可以在多种成像的指导下对肿瘤进行精确治疗。因此，本文综述了近年来天然产物与金属离子配位在癌症治疗中的应用研究进展。此外，还讨论了天然产物与金属离子配位的应用前景和挑战，特别是如何提高靶向能力和稳定性以及评估金属离子的安全性，从而促进天然产物与金属离子配位纳米药物的临床转化和应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/aa64fb7c0b75/12951_2024_2981_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/2e83427da68e/12951_2024_2981_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/79b3798eed3d/12951_2024_2981_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/a46a2734eda1/12951_2024_2981_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/6f7e8e97822f/12951_2024_2981_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/34fcc2c8a249/12951_2024_2981_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/7893d940db3a/12951_2024_2981_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/e1d7bd8a4c57/12951_2024_2981_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/aa64fb7c0b75/12951_2024_2981_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/2e83427da68e/12951_2024_2981_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/79b3798eed3d/12951_2024_2981_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/a46a2734eda1/12951_2024_2981_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/6f7e8e97822f/12951_2024_2981_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/34fcc2c8a249/12951_2024_2981_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/7893d940db3a/12951_2024_2981_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/e1d7bd8a4c57/12951_2024_2981_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809b/11580416/aa64fb7c0b75/12951_2024_2981_Fig8_HTML.jpg

相似文献

[1]
An encounter between metal ions and natural products: natural products-coordinated metal ions for the diagnosis and treatment of tumors.

J Nanobiotechnology. 2024-11-21

[2]
Metal-Coordinated Supramolecular Self-Assemblies for Cancer Theranostics.

Adv Sci (Weinh). 2021-8

[3]
Recent advances in self-targeting natural product-based nanomedicines.

J Nanobiotechnology. 2025-1-20

[4]
Delivery of natural products via polysaccharide-based nanocarriers for cancer therapy: A review on recent advances and future challenges.

Int J Biol Macromol. 2024-10

[5]
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges.

Drug Deliv Transl Res. 2024-10

[6]
Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular "ion overload" for cancer treatment.

Mater Horiz. 2024-9-16

[7]
Nanomedicine for combination of chemodynamic therapy and immunotherapy of cancers.

Biomater Sci. 2024-9-10

[8]
Anticancer nanomedicines harnessing tumor microenvironmental components.

Expert Opin Drug Deliv. 2022-4

[9]
Approved natural products-derived nanomedicines for disease treatment.

Chin J Nat Med. 2024-12

[10]
Combining Nanomedicine and Immunotherapy.

Acc Chem Res. 2019-5-23

引用本文的文献

[1]
Fluorescent-Electrochemical-Colorimetric Triple-Model Immunoassays with Multifunctional Metal-Organic Frameworks for Signal Amplification.

Biosensors (Basel). 2025-6-11

[2]
How Traditional Chinese Medicine Can Play a Role In Nanomedicine? A Comprehensive Review of the Literature.

Int J Nanomedicine. 2025-5-20

[3]
Recent advances in self-targeting natural product-based nanomedicines.

J Nanobiotechnology. 2025-1-20

本文引用的文献

[1]
All-in-one nanotheranostic platform based on tumor microenvironment: new strategies in multimodal imaging and therapeutic protocol.

Drug Discov Today. 2024-7

[2]
Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy.

Pharmacol Res. 2024-5

[3]
Robust reactive oxygen species modulator hitchhiking yeast microcapsules for colitis alleviation by trilogically intestinal microenvironment renovation.

Bioact Mater. 2024-3-5

[4]
Role of zinc in health and disease.

Clin Exp Med. 2024-2-17

[5]
ESPEN practical short micronutrient guideline.

Clin Nutr. 2024-3

[6]
Vanadium Compounds with Antidiabetic Potential.

Int J Mol Sci. 2023-10-27

[7]
Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma.

J Nanobiotechnology. 2023-10-19

[8]
An injectable PCARGD/Cu/DOX hydrogel for combined chemodynamic and chemotherapy of tumors.

J Biomater Sci Polym Ed. 2024-2

[9]
Ultrasmall Bi/Cu Coordination Polymer Combined with Glucose Oxidase for Tumor Enhanced Chemodynamic Therapy by Starvation and Photothermal Treatment.

Adv Healthc Mater. 2024-1

[10]
Self-delivery of a metal-coordinated anti-angiogenic nanodrug with GSH depleting ability for synergistic chemo-phototherapy.

Biomater Sci. 2023-10-24

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索