School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
J Nanobiotechnology. 2024 Nov 21;22(1):726. doi: 10.1186/s12951-024-02981-9.
Natural products-coordinated metal ions to form the nanomedicines are in the spotlight for cancer therapy. Some natural products could be coordinated with metal ions forming nanomedicines via simple and green environmental self-assembly, which not only improved the bioavailability of natural products, but also conferred multiple therapeutic modalities and multimodal imaging. On the one hand, in the weak acidity, glutathione (GSH) and hydrogen peroxide (HO) overexpression of tumor microenvironment (TME), such carrier-free nanomedicines could be further enhanced the therapeutic effect via optimizing the species of metal ions. On the other hand, nanomedicines could exert the precise treatment of tumor under the guidance of multiple imaging. Hence, this review summarized the research progress in recent years on the application of natural product-coordinated metal ions in cancer therapy. In addition, the prospects and challenges for the application of natural product-coordinated metal ions were discussed, especially how to improve targeting ability and stability and assess the safety of metal ions, so as to facilitate the clinical translation and application of natural product-coordinated metal ions nanomedicines.
天然产物与金属离子配位形成的纳米药物是癌症治疗的焦点。一些天然产物可以通过简单、绿色的环境自组装与金属离子配位形成纳米药物，不仅提高了天然产物的生物利用度，而且赋予了多种治疗模式和多模态成像。一方面，在肿瘤微环境（TME）的弱酸性、谷胱甘肽（GSH）和过氧化氢（HO）过表达的情况下，这种无载体的纳米药物可以通过优化金属离子的种类进一步增强治疗效果。另一方面，纳米药物可以在多种成像的指导下对肿瘤进行精确治疗。因此，本文综述了近年来天然产物与金属离子配位在癌症治疗中的应用研究进展。此外，还讨论了天然产物与金属离子配位的应用前景和挑战，特别是如何提高靶向能力和稳定性以及评估金属离子的安全性，从而促进天然产物与金属离子配位纳米药物的临床转化和应用。
