College of Chemistry, Liaoning University, 66 Chongshan Middle Road, Shenyang, 110036, People's Republic of China.
Mikrochim Acta. 2021 Jan 26;188(2):52. doi: 10.1007/s00604-021-04708-1.
A low cost-effective and simple synthesis method was adopted to acquire three-dimensional flower-like structure FeO/C that has large specific area, suitable pore structure and sufficient saturation magnetism. The obtained FeO/C exhibits outstanding preconcentration ability and was applied to extracting non-steroidal anti-inflammatory drugs from complex environmental and biological samples. The parameters of magnetic solid-phase extraction were optimized by univariate and multivariate methods (Box-Behnken design). The high degree of linearity from 2.5 to 1000.0 ng mL (R ≥ 0.9976), the limits of detection from 0.25 to 0.5 ng mL (S/N = 3), and the limits of quantitation from 1.0 to 2.0 ng mL (S/N = 10) were yielded by adopting this novel method after the optimization. Moreover, the recoveries of non-steroidal anti-inflammatory drugs from 89.6 to 107.0% were acquired in spiked plasma, urine and lake samples. In addition, the adsorption of non-steroidal anti-inflammatory drugs on FeO/C was explored by adsorption isotherms and kinetic studies. Furthermore, the adsorption mechanism for non-steroidal anti-inflammatory drugs by FeO/C was proposed, which was hydrogen bonding and π-π interaction between non-steroidal anti-inflammatory drugs and FeO/C. Graphical abstract.
采用一种低成本、有效的简单合成方法，获得了具有大比表面积、合适的孔结构和充足饱和磁化强度的三维花状结构 FeO/C。所得 FeO/C 表现出优异的预浓缩能力，并应用于从复杂环境和生物样品中提取非甾体抗炎药。通过单变量和多变量方法（Box-Behnken 设计）优化了磁固相萃取的参数。通过优化后，采用这种新方法在 2.5 至 1000.0ngmL（R≥0.9976）的高线性度范围内，检测限从 0.25 至 0.5ngmL（S/N=3），定量限从 1.0 至 2.0ngmL（S/N=10）。此外，在加标血浆、尿液和湖水样品中，非甾体抗炎药的回收率为 89.6%至 107.0%。此外，还通过吸附等温线和动力学研究探讨了非甾体抗炎药在 FeO/C 上的吸附。进一步提出了 FeO/C 对非甾体抗炎药的吸附机理，即非甾体抗炎药与 FeO/C 之间的氢键和π-π相互作用。
