Department of Emergency Room and General Medicine, Ageo Central General Hospital, Saitama, Japan.
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1, Oyaguchikami-machi, Itabashi-ku, Tokyo, 173-8610, Japan.
Aging Clin Exp Res. 2021 Sep;33(9):2511-2517. doi: 10.1007/s40520-021-01787-1. Epub 2021 Jan 26.
The timed up and go (TUG) test assesses balance and mobility performance.
This study aims to investigate the association between TUG time and mortality in Japanese older persons and to clarify possible moderation effects on mortality and TUG time.
In all, 874 participants who were ≥ 65 years of age completed the TUG test and had their anthropometric parameters and physical functions measured. We investigated the association between all-cause mortality and TUG using a Cox regression model that included confounders, and explored the time associated with mortality using a restricted cubic spline. We also performed subgroup analyses to explore whether age, sex, and body mass index (BMI) affected the relationship between TUG time and mortality.
The median age and mean follow-up period were 74 and 8.5 years, respectively. Median TUG time was 7.4 s and the prevalence of mortality was 25.7%. TUG time in one second was positively associated with an increased risk of total mortality [hazard ratio (HR): 1.054 (1.016-1.093); P = 0.005] in the Cox regression model. The positive association of mortality and TUG time was present when the TUG was over 10.5 s in the restricted cubic spline curve. Older age (75 years or older) moderated the relationship between TUG time and mortality [P = 0.096].
This study demonstrates that TUG time is associated with all-cause mortality in Japanese older adults.
计时起立行走测试（TUG）评估平衡和移动性能。
本研究旨在探讨 TUG 时间与日本老年人死亡率之间的关系，并阐明 TUG 时间与死亡率之间可能存在的调节作用。
共有 874 名年龄≥65 岁的参与者完成了 TUG 测试，并测量了他们的人体测量参数和身体功能。我们使用包含混杂因素的 Cox 回归模型调查了全因死亡率与 TUG 之间的关系，并使用限制三次样条探索与死亡率相关的时间。我们还进行了亚组分析，以探讨年龄、性别和体重指数（BMI）是否影响 TUG 时间与死亡率之间的关系。
中位年龄和平均随访期分别为 74 岁和 8.5 年。TUG 时间的中位数为 7.4 秒，死亡率的患病率为 25.7%。在 Cox 回归模型中，TUG 时间增加一秒与总死亡率增加的风险呈正相关[风险比（HR）：1.054（1.016-1.093）；P=0.005]。在限制三次样条曲线中，当 TUG 超过 10.5 秒时，死亡率与 TUG 时间之间的正相关关系仍然存在。年龄较大（75 岁或以上）调节了 TUG 时间与死亡率之间的关系[P=0.096]。
本研究表明，TUG 时间与日本老年人的全因死亡率相关。
