Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine.
Division of General Medicine, Department of Internal Medicine, Nihon University School of Medicine.
J Atheroscler Thromb. 2019 Apr 1;26(4):328-339. doi: 10.5551/jat.45609. Epub 2018 Aug 22.
Adiponectin exhibits its biological effects through adiponectin receptors (AdipoR1 and AdipoR2), which are distributed in the kidneys, and activation of those receptors could prevent or ameliorate diabetic nephropathy. This study aimed to evaluate the associations between AdipoR single nucleotide polymorphisms (SNPs) and kidney function in an elderly Japanese population.
A total of 271 elderly Japanese volunteers underwent anthropometric and laboratory tests (cystatin C-based eGFR and total and high molecular weight adiponectin levels at baseline and a follow-up visit). Genotype data were obtained for the selected 7 and 5 AdipoR1 and AdipoR2 SNPs, respectively.
In a cross-sectional analysis at baseline, we found a significant association between the AdipoR2 SNP rs12230440 and kidney function; eGFRcys tended to increase as the number of carriers of T alleles increased after adjustment for covariates and Bonferroni correction, although the association of the SNP and annual eGFR decline could not be identified in the longitudinal data. Regarding the variants rs16850797, rs11061925, and rs10773983, each of the allele G, allele C, and allele G showed nominally significant associations with higher eGFRcys. However, this failed to reach significance after Bonferroni correction.
Here, an AdipoR2 SNP was associated with kidney function, suggesting that the effects of this polymorphism on adiponectin receptor may affect kidney function in the elderly Japanese population.
脂联素通过脂联素受体（AdipoR1 和 AdipoR2）发挥其生物学作用，这些受体分布在肾脏中，激活这些受体可以预防或改善糖尿病肾病。本研究旨在评估老年日本人群中脂联素受体单核苷酸多态性（SNP）与肾功能之间的关系。
共有 271 名老年日本志愿者接受了人体测量学和实验室检查（基线和随访时基于胱抑素 C 的 eGFR 以及总和高分子量脂联素水平）。分别获得了选定的 7 个和 5 个 AdipoR1 和 AdipoR2 SNP 的基因型数据。
在基线的横断面分析中，我们发现 AdipoR2 SNP rs12230440 与肾功能之间存在显著关联；在调整了协变量和 Bonferroni 校正后，eGFRcys 随着 T 等位基因携带者数量的增加而趋于增加，尽管在纵向数据中无法确定 SNP 与每年 eGFR 下降之间的关联。关于 rs16850797、rs11061925 和 rs10773983 这三个变体，每个 G 等位基因、C 等位基因和 G 等位基因都与较高的 eGFRcys 呈名义上显著相关。然而，在经过 Bonferroni 校正后，这种关联失去了统计学意义。
本研究中，AdipoR2 SNP 与肾功能相关，表明该多态性对脂联素受体的影响可能会影响老年日本人群的肾功能。
