Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, Qingdao, China.
Department of Geriatrics, Affiliated Hospital of Qingdao University, Qingdao, China.
Arch Gerontol Geriatr. 2019 Sep-Oct;84:103895. doi: 10.1016/j.archger.2019.05.020. Epub 2019 May 28.
To estimate whether the associations of obesity, physical activity, vision and grip strength with functional mobility were modified by age.
Data from The Irish Longitudinal Study on Ageing (2009-2012) were analyzed and 5001 individuals were included in this study. Mobility was assessed by the timed up and go test (TUG-test). Main exposure variables were obesity, physical activity, visual acuity and grip strength at baseline. Multiple linear regression models were fitted to assess the associations of baseline main exposure variables with 2-year follow-up functional mobility and potential confounders were adjusted. Stratified analyses by age were used to assess the interaction between main exposures and age on functional mobility.
Multiple linear regression models identified significant interactions of obesity (P < 0.001), vigorous physical activity (P = 0.001), vision (P < 0.001) and grip strength (P < 0.001) with age on functional mobility. Stratified analyses suggested that the risk effect of obesity on functional mobility was greater in middle-aged group (β = 0.025, P < 0.001) than in older group (β = 0.016, P = 0.017). The protective effects of high level of physical activity and grip strength on functional mobility were stronger in older group (β = -0.023, P = 0.004 for physical activity; β = -0.002, P < 0.001 for grip strength) than in middle-aged group (β = -0.012, P = 0.008 for physical activity; β = -0.0015, P < 0.001 for grip strength). The benefit of better vision on functional mobility was observed in middle-aged group only (β = -0.032, P = 0.002).
Non-obesity, higher level of physical activity, vision and grip strength at baseline were associated with better mobility performance among middle-aged and older Irish. And these associations were modified by age.
评估肥胖、身体活动、视力和握力与功能性移动能力的关联是否因年龄而改变。
对爱尔兰老龄化纵向研究（2009-2012 年）的数据进行分析，纳入本研究的 5001 人。通过计时起立行走测试（TUG 测试）评估移动能力。主要暴露变量为基线时的肥胖、身体活动、视力和握力。拟合多元线性回归模型，以评估基线主要暴露变量与 2 年随访功能移动能力的相关性，并调整潜在的混杂因素。按年龄进行分层分析，以评估主要暴露与年龄对功能移动能力的交互作用。
多元线性回归模型确定肥胖（P<0.001）、剧烈身体活动（P=0.001）、视力（P<0.001）和握力（P<0.001）与功能性移动能力的交互作用有统计学意义。分层分析表明，肥胖对中老年人（β=0.025，P<0.001）功能性移动能力的风险效应大于老年人（β=0.016，P=0.017）。高身体活动水平和握力对功能性移动能力的保护作用在老年人（β=-0.023，P=0.004 用于身体活动；β=-0.002，P<0.001 用于握力）比中老年人（β=-0.012，P=0.008 用于身体活动；β=-0.0015，P<0.001 用于握力）更强。仅在中年组观察到更好的视力对功能性移动能力的有益影响（β=-0.032，P=0.002）。
基线时非肥胖、更高水平的身体活动、视力和握力与爱尔兰中老年人更好的移动能力相关，且这些关联受年龄影响。
