University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
Can J Ophthalmol. 2021 Apr;56(2):83-87. doi: 10.1016/j.jcjo.2020.12.021. Epub 2021 Jan 9.
To examine the changes in choriocapillaris and retina caused by coronavirus disease 2019 (COVID-19) by comparing optical coherence tomography angiography (OCTA) findings of COVID-19 patients and healthy controls.
The study and control groups consisted of 54 eyes of 27 participants, each. Patients and controls underwent OCTA examination. Foveal zone vessel density and parafoveal zone vessel density (for 4 quadrants: nasal, temporal, superior, inferior) were calculated for both superficial and deep capillary plexuses. Additionally, choriocapillaris flow and foveal avascular zone areas were calculated.
For the parafoveal area in the study group, vessel density was significantly lower in the superior and nasal quadrants of the superficial capillary plexus and in all quadrants of the deep capillary plexus compared with controls (p < 0.05 for all). The study group had significantly higher choriocapillaris flow area values compared with controls (p = 0.042).
Reduced vessel density of the retinal capillary plexus was detected in COVID-19 patients who may be at risk for retinal vascular complications.
通过比较 COVID-19 患者和健康对照者的光学相干断层扫描血管造影（OCTA）结果，研究 COVID-19 引起的脉络膜毛细血管和视网膜的变化。
研究组和对照组各包含 27 名参与者的 54 只眼。对患者和对照者均行 OCTA 检查。计算浅层和深层毛细血管丛的中心凹区血管密度和旁中心凹区血管密度（4 个象限：鼻侧、颞侧、上方、下方）。此外，还计算脉络膜毛细血管血流和中心凹无血管区面积。
研究组的旁中心凹区，浅层毛细血管丛的上方和鼻侧象限以及深层毛细血管丛的所有象限的血管密度均显著低于对照组（p<0.05）。与对照组相比，研究组的脉络膜毛细血管血流面积值显著更高（p=0.042）。
COVID-19 患者的视网膜毛细血管丛血管密度降低，其可能有发生视网膜血管并发症的风险。
