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眼镜蛇(Bungarus caeruleus)咬伤导致的异常延长的神经肌肉无力:两例报告。

Unusually prolonged neuromuscular weakness caused by krait (Bungarus caeruleus) bite: Two case reports.

机构信息

University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.

出版信息

Toxicon. 2021 Apr 15;193:1-3. doi: 10.1016/j.toxicon.2021.01.011. Epub 2021 Jan 23.

Abstract

Snakebites are common in India and the most common neurotoxic snakebites in India are due to Common krait (Bungarus caeruleus) and cobra (Naja naja). Severe envenomation may mimic brain death or a locked-in state with flaccid paralysis in a descending manner and total ophthalmoplegia. Usually, patients who receive timely antivenom and ventilator support recover completely without any sequalae. We are reporting two cases of krait bite with an unusually long period of flaccid paralysis, which required prolong ventilation. While case 1 required 10 days of mechanical ventilation followed by 5 days of non-invasive ventilation, case 2 required 11 days of mechanical ventilation followed by 5 days of non-invasive ventilation. Both the cases had delayed recovery and residual weakness at 3-month follow up. These case reports suggest that krait bite may cause prolong neuromuscular weakness in children, which has implications for both acute and chronic management.

摘要

在印度,蛇咬伤很常见,而最常见的神经毒性蛇咬伤是由金环蛇(Bungarus caeruleus)和眼镜蛇(Naja naja)引起的。严重的中毒可能表现为类似于脑死亡或闭锁状态,出现弛缓性瘫痪,并伴有完全性眼肌瘫痪。通常情况下,及时接受抗蛇毒血清和呼吸机支持治疗的患者可以完全康复,没有任何后遗症。我们报告了两例金环蛇咬伤病例,这些病例出现了异常长的弛缓性瘫痪,需要长时间通气。其中一例需要机械通气 10 天,然后进行无创通气 5 天;另一例则需要机械通气 11 天,然后进行无创通气 5 天。这两例病例在 3 个月的随访中都出现了延迟恢复和残留无力的情况。这些病例报告表明,金环蛇咬伤可能导致儿童出现长时间的神经肌肉无力,这对急性和慢性管理都有影响。

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