García-Aguilar Ana, Palomino Olga, Benito Manuel, Guillén Carlos
Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, University Complutense of Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
Antioxidants (Basel). 2021 Jan 20;10(2):142. doi: 10.3390/antiox10020142.
Polyphenols represent a group of secondary metabolites of plants which have been analyzed as potent regulators of multiple biological processes, including cell proliferation, apoptosis, and autophagy, among others. These natural compounds exhibit beneficial effects and protection against inflammation, oxidative stress, and related injuries including metabolic diseases, such as cardiovascular damage, obesity and diabetes, and neurodegeneration. This review aims to summarize the mechanisms of action of polyphenols in relation to the activation of autophagy, stimulation of mitochondrial function and antioxidant defenses, attenuation of oxidative stress, and reduction in cell apoptosis, which may be responsible of the health promoting properties of these compounds.
多酚是植物的一组次生代谢产物，已被分析为多种生物过程的有效调节剂，包括细胞增殖、凋亡和自噬等。这些天然化合物具有有益作用，并能预防炎症、氧化应激以及包括代谢性疾病（如心血管损伤、肥胖症和糖尿病）和神经退行性变在内的相关损伤。本综述旨在总结多酚在自噬激活、线粒体功能和抗氧化防御刺激、氧化应激减轻以及细胞凋亡减少方面的作用机制，这些机制可能是这些化合物促进健康特性的原因。
