Reagan Michaela R, Fairfield Heather, Rosen Clifford J
Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, ME 04074, USA.
School of Medicine, Tufts University, Boston, MA 02111, USA.
Cancers (Basel). 2021 Jan 20;13(3):364. doi: 10.3390/cancers13030364.
Cancers that grow in the bone marrow are for most patients scary, painful, and incurable. These cancers are especially hard to treat due to the supportive microenvironment provided by the bone marrow niche in which they reside. New therapies designed to target tumor cells have extended the life expectancy for these patients, but better therapies are needed and new ideas for how to target these cancers are crucial. This need has led researchers to interrogate whether bone marrow adipocytes (BMAds), which increase in number and size during aging and in obesity, contribute to cancer initiation or progression within the bone marrow. Across the globe, the consensus in the field is a unified "yes". However, how to target these adipocytes or the factors they produce and how BMAds interact with different tumor cells are open research questions. Herein, we review this research field, with the goal of accelerating research in the network of laboratories working in this area and attracting bright scientists with new perspectives and ideas to the field in order to bring about better therapies for patients with bone cancers.
对大多数患者来说，生长在骨髓中的癌症既可怕、疼痛又无法治愈。由于这些癌症所处的骨髓微环境提供支持，它们尤其难以治疗。旨在靶向肿瘤细胞的新疗法延长了这些患者的预期寿命，但仍需要更好的疗法，想出针对这些癌症的新方法至关重要。这种需求促使研究人员探究骨髓脂肪细胞（BMAds）是否在衰老和肥胖过程中数量和大小增加，从而促进骨髓内癌症的发生或进展。在全球范围内，该领域的共识是一致的“是”。然而，如何靶向这些脂肪细胞或它们产生的因子，以及BMAds如何与不同肿瘤细胞相互作用，仍是有待研究的问题。在此，我们对该研究领域进行综述，目的是加快在该领域开展工作的实验室网络的研究，并吸引有新观点和想法的优秀科学家投身该领域，以便为骨癌患者带来更好的治疗方法。
