Xu Junpeng, Fu Chih-Yu, Tsai Yu-Liang, Wong Chui-Wei, Hsu Shan-Hui
Institute of Polymer Science and Engineering, National Taiwan University, No. 1, Sec. 4 Roosevelt Road, Taipei 10617, Taiwan.
Institute of Cellular and System Medicine, National Health Research Institutes, No. 35 Keyan Road, Miaoli 35053, Taiwan.
Polymers (Basel). 2021 Jan 20;13(3):326. doi: 10.3390/polym13030326.
Conductive thin films have great potential for application in the biomedical field. Herein, we designed thermoresponsive and conductive thin films with hydrophilicity, strain sensing, and biocompatibility. The crosslinked dense thin films were synthesized and prepared through a Schiff base reaction and ionic interaction from dialdehyde polyurethane, N-carboxyethyl chitosan, and double-bonded chitosan grafted polypyrrole. The thin films were air-dried under room temperature. These thin films showed hydrophilicity and conductivity (above 2.50 mS/cm) as well as responsiveness to the deformation. The tensile break strength (9.72 MPa to 15.07 MPa) and tensile elongation (5.76% to 12.77%) of conductive thin films were enhanced by heating them from 25 °C to 50 °C. In addition, neural stem cells cultured on the conductive thin films showed cell clustering, proliferation, and differentiation. The application of the materials as a conductive surface coating was verified by different coating strategies. The conductive thin films are potential candidates for surface modification and biocompatible polymer coating.
导电薄膜在生物医学领域具有巨大的应用潜力。在此，我们设计了具有亲水性、应变传感和生物相容性的热响应性导电薄膜。通过席夫碱反应和离子相互作用，由二醛聚氨酯、N-羧乙基壳聚糖和双键接枝聚吡咯的壳聚糖合成并制备了交联致密薄膜。薄膜在室温下空气干燥。这些薄膜表现出亲水性和导电性（高于2.50 mS/cm）以及对变形的响应性。通过将导电薄膜从25℃加热到50℃，其拉伸断裂强度（9.72 MPa至15.07 MPa）和拉伸伸长率（5.76%至12.77%）得到提高。此外，在导电薄膜上培养的神经干细胞表现出细胞聚集、增殖和分化。通过不同的涂层策略验证了该材料作为导电表面涂层的应用。导电薄膜是表面改性和生物相容性聚合物涂层的潜在候选材料。
