Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, Poland.
Int J Mol Sci. 2021 Jan 20;22(3):1009. doi: 10.3390/ijms22031009.
The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity. The chemical classes discussed in this paper include inorganic (selenite, selenate) and organic compounds, such as diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one and selenophene-based derivatives, as well as selenoamino acids and Selol.
高数量的新癌症发病率和相关死亡率仍然令人震惊，这导致人们一直在寻找新的治疗方法，这些方法对患者更有效且负担更小。由于有证据表明硒化合物具有化学预防活性，因此已经开始研究这些化合物是否也会影响已经存在的癌症。这篇综述旨在讨论不同类别的含硒化合物，包括有机和无机、天然和合成的化合物，以及它们抗癌活性的机制和分子靶点。本文讨论的化学类别包括无机（亚硒酸盐、硒酸盐）和有机化合物，如二硒化物、硒化物、硒酯、甲基硒酸、1,2-苯并异硒唑-3[2H]-酮和基于硒吩的衍生物，以及硒代氨基酸和 Selol。
