Nolan C M, Elarth A M, Barr H W
Seattle-King County Department of Public Health, University of Washington.
Chest. 1988 Apr;93(4):803-6. doi: 10.1378/chest.93.4.803.
During a two-year period, from January 1984 through December 1985, six cases of intentional overdosage with isoniazid were reported in young Southeast Asian refugee women. The patients were aged 14 to 23 years, had all immigrated within one year and were receiving isoniazid preventive therapy for tuberculosis infection without disease. Clinically, all patients experienced generalized seizures, and three sustained moderate metabolic acidosis. All recovered uneventfully. Psychiatric evaluations revealed that two patients had major depression; two, adjustment disorders with depressed mood; and two, no psychiatric illness. The latter two patients and two others ingested an excessive amount of isoniazid immediately following an argument with a family member. Because tuberculosis infection is prevalent in refugees immigrating from Southeast Asia, isoniazid, given for six months to one year as preventive therapy, is one of the most frequently prescribed drugs during the early resettlement period. There may be an increased risk of intentional isoniazid overdosage during preventive therapy of young refugee women.
在1984年1月至1985年12月的两年期间，有6例东南亚年轻难民女性故意过量服用异烟肼的病例报告。这些患者年龄在14至23岁之间，均在一年内移民，且因结核感染但无疾病而接受异烟肼预防性治疗。临床上，所有患者均出现全身性癫痫发作，3例出现中度代谢性酸中毒。所有患者均顺利康复。精神病学评估显示，2例患者患有重度抑郁症；2例患有伴情绪低落的适应障碍；2例无精神疾病。后2例患者以及另外2例患者在与家庭成员发生争吵后立即过量服用了异烟肼。由于从东南亚移民的难民中结核感染很普遍，因此作为预防性治疗给予6个月至1年的异烟肼是重新安置初期最常开具的药物之一。在年轻难民女性的预防性治疗期间，故意过量服用异烟肼的风险可能会增加。
