Huang Mengna, Kelly Rachel S, Chu Su H, Kachroo Priyadarshini, Gürdeniz Gözde, Chawes Bo L, Bisgaard Hans, Weiss Scott T, Lasky-Su Jessica
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.
Metabolites. 2021 Jan 23;11(2):65. doi: 10.3390/metabo11020065.
The in utero environment during pregnancy has important implications for the developing health of the child. We aim to examine the potential impact of maternal metabolome at two different timepoints in pregnancy on offspring respiratory health in early life. In 685 mother-child pairs from the Vitamin D Antenatal Asthma Reduction Trial, we assessed the prospective associations between maternal metabolites at both baseline (10-18 weeks gestation) and third trimester (32-38 weeks gestation) and the risk of child asthma or recurrent wheeze by age three using logistic regression models accounting for confounding factors. Subgroup analyses were performed by child sex. Among 632 metabolites, 19 (3.0%) and 62 (9.8%) from baseline and third trimester, respectively, were associated with the outcome (-value < 0.05). Coffee-related metabolites in the maternal metabolome appeared to be of particular importance. Caffeine, theophylline, trigonelline, quinate, and 3-hydroxypyridine sulfate were inversely associated with asthma risk at a minimum of one timepoint. Additional observations also highlight the roles of steroid and sphingolipid metabolites. Overall, there was a stronger relationship between the metabolome in later pregnancy and offspring asthma risk. Our results suggest that alterations in prenatal metabolites may act as drivers of the development of offspring asthma.
孕期的子宫内环境对儿童的健康发育具有重要影响。我们旨在研究孕期两个不同时间点的母体代谢组对儿童早期呼吸健康的潜在影响。在维生素D预防哮喘试验中的685对母婴中，我们使用考虑混杂因素的逻辑回归模型，评估了孕早期（妊娠10 - 18周）和孕晚期（妊娠32 - 38周）母体代谢物与三岁儿童患哮喘或复发性喘息风险之间的前瞻性关联。按儿童性别进行亚组分析。在632种代谢物中，分别有19种（3.0%）和62种（9.8%）在孕早期和孕晚期与研究结果相关（P值<0.05）。母体代谢组中与咖啡相关的代谢物似乎尤为重要。咖啡因、茶碱、胡芦巴碱、奎尼酸和3 - 羟基吡啶硫酸盐在至少一个时间点与哮喘风险呈负相关。其他观察结果也突出了类固醇和鞘脂代谢物的作用。总体而言，孕晚期的代谢组与后代哮喘风险之间的关系更强。我们的结果表明，产前代谢物的改变可能是后代哮喘发展的驱动因素。
