Azienda Ospedaliera San Camillo Forlanini Hospital, 00152 Roma, Italy.
Department of Surgical Sciences, Sapienza University, 00152 Rome, Italy.
Int J Mol Sci. 2021 Jan 23;22(3):1121. doi: 10.3390/ijms22031121.
Kidney transplantation is the golden treatment for end-stage renal disease. Static cold storage is currently considered the standard method of preservation, but dynamic techniques, such as machine perfusion (MP), have been shown to improve graft function, especially in kidneys donated by extended criteria donors and donation after circulatory death. With poor organ quality being a major reason for kidneys not being transplanted, an accurate, objective and reliable quality assessment during preservation could add value and support to clinicians' decisions. MPs are emerging technologies with the potential to assess kidney graft viability and quality, both in the hypothermic and normothermic scenarios. The aim of this review is to summarize current tools for graft viability assessment using MP prior to implantation in relation to the ischemic damage.
肾移植是治疗终末期肾病的金标准。目前，静态冷保存被认为是保存的标准方法，但动态技术，如机器灌注 (MP)，已被证明可以改善移植物功能，特别是在延长标准供体和循环死亡后捐献的肾脏中。由于器官质量差是肾脏未被移植的主要原因，如果在保存过程中能够进行准确、客观和可靠的质量评估，将为临床医生的决策提供更多价值。MP 是一种新兴技术，具有在低温和常温两种情况下评估肾移植物活力和质量的潜力。本综述的目的是总结目前在植入前使用 MP 评估移植物活力的工具，以及与缺血损伤的关系。
