Klatt Megan E, Eschenauer Gregory A
Department of Clinical Pharmacy, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, MI 48109, USA.
J Fungi (Basel). 2021 Jan 22;7(2):76. doi: 10.3390/jof7020076.
Mold-active azole antifungals are commonly prescribed for the prevention of invasive fungal infections in lung transplant recipients. Each agent exhibits a unique pharmacologic profile, an understanding of which is crucial for therapy selection and optimization. This article reviews pharmacologic considerations for three frequently-used azole antifungals in lung transplant recipients: voriconazole, posaconazole, and isavuconazole. Focus is drawn to analysis of drug-interactions, adverse drug reactions, pharmacokinetic considerations, and the role of therapeutic drug monitoring with special emphasis on data from the post-lung transplant population.
具有抗霉菌活性的唑类抗真菌药常用于预防肺移植受者的侵袭性真菌感染。每种药物都有其独特的药理学特性，了解这些特性对于治疗方案的选择和优化至关重要。本文综述了肺移植受者常用的三种唑类抗真菌药（伏立康唑、泊沙康唑和艾沙康唑）的药理学考量因素。重点分析了药物相互作用、药物不良反应、药代动力学考量因素以及治疗药物监测的作用，特别强调了肺移植后人群的数据。
