Talapko Jasminka, Juzbašić Martina, Matijević Tatjana, Pustijanac Emina, Bekić Sanja, Kotris Ivan, Škrlec Ivana
Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, HR-31000 Osijek, Croatia.
Department of Dermatology and Venereology, Clinical Hospital Center Osijek, HR-31000 Osijek, Croatia.
J Fungi (Basel). 2021 Jan 22;7(2):79. doi: 10.3390/jof7020079.
is a common commensal fungus that colonizes the oropharyngeal cavity, gastrointestinal and vaginal tract, and healthy individuals' skin. In 50% of the population, is part of the normal flora of the microbiota. The various clinical manifestations of species range from localized, superficial mucocutaneous disorders to invasive diseases that involve multiple organ systems and are life-threatening. From systemic and local to hereditary and environmental, diverse factors lead to disturbances in 's normal homeostasis, resulting in a transition from normal flora to pathogenic and opportunistic infections. The transition in the pathophysiology of the onset and progression of infection is also influenced by 's virulence traits that lead to the development of candidiasis. Oral candidiasis has a wide range of clinical manifestations, divided into primary and secondary candidiasis. The main supply of in the body is located in the gastrointestinal tract, and the development of infections occurs due to dysbiosis of the residential microbiota, immune dysfunction, and damage to the muco-intestinal barrier. The presence of in the blood is associated with candidemia-invasive infections. The commensal relationship exists as long as there is a balance between the host immune system and the virulence factors of . This paper presents the virulence traits of and clinical manifestations of specific candidiasis.
是一种常见的共生真菌，可定殖于口咽腔、胃肠道、阴道以及健康个体的皮肤。在50%的人群中，它是微生物群正常菌群的一部分。该菌种的各种临床表现范围从局部、浅表的黏膜皮肤疾病到累及多个器官系统且危及生命的侵袭性疾病。从全身和局部到遗传和环境，多种因素导致其正常稳态受到干扰，从而使其从正常菌群转变为致病性和机会性感染。感染发生和进展的病理生理学转变也受其毒力特征影响，这些特征会导致念珠菌病的发展。口腔念珠菌病有多种临床表现，分为原发性和继发性念珠菌病。人体中该菌的主要来源位于胃肠道，感染的发生是由于常驻微生物群失调、免疫功能障碍以及黏膜肠道屏障受损。血液中该菌的存在与念珠菌血症——侵袭性感染相关。只要宿主免疫系统与该菌的毒力因子之间保持平衡，共生关系就会存在。本文介绍了该菌的毒力特征以及特定念珠菌病的临床表现。
