Zhang K, Shen Z A
Department of Burns and Plastic Surgery, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100048, China.
Zhonghua Shao Shang Za Zhi. 2021 Jan 20;37(1):89-92. doi: 10.3760/cma.j.cn501120-20200106-00007.
Keratinocytes (KCs) are the main cells that constitute the epidermis, which have immunogenicity and play important roles in immunity. KCs-mediated immune response plays an initiating role in the innate immune response. KCs recognize antigens mainly through Toll-like receptors and nucleotide-binding oligomerization domain-like receptors. After being activated, KCs up-regulate the expressions of cytokines, chemokines, and antibacterial peptides via signal transduction pathways and help initiate skin immune response. KCs also participate in early innate immune response by attracting inflammatory cells and innate immune cells such as mast cells and macrophages. Studies on the molecular biological mechanism and regulatory measures of KCs' immunogenicity are of great significance for the construction of skin substitutes such as cell sheets to repair wounds. This article reviews the research advances in immunological properties and gene regulation of KCs.
角质形成细胞（KCs）是构成表皮的主要细胞，具有免疫原性并在免疫中发挥重要作用。KCs介导的免疫反应在先天免疫反应中起启动作用。KCs主要通过Toll样受体和核苷酸结合寡聚化结构域样受体识别抗原。激活后，KCs通过信号转导途径上调细胞因子、趋化因子和抗菌肽的表达，并有助于启动皮肤免疫反应。KCs还通过吸引炎症细胞和先天免疫细胞如肥大细胞和巨噬细胞参与早期先天免疫反应。研究KCs免疫原性的分子生物学机制和调控措施对于构建如细胞片等皮肤替代物来修复伤口具有重要意义。本文综述了KCs免疫特性和基因调控的研究进展。
