间碘苄胍在儿童神经母细胞瘤中的生物分布及药代动力学
The biodistribution and pharmacokinetics of meta-iodobenzylguanidine in childhood neuroblastoma.
作者信息
Lashford L S, Moyes J, Ott R, Fielding S, Babich J, Mellors S, Gordon I, Evans K, Kemshead J T
机构信息
ICRF Oncology Laboratory, Institute of Child Health, London, UK.
出版信息
Eur J Nucl Med. 1988;13(11):574-7. doi: 10.1007/BF02574771.
MIBG is generating considerable interest for the treatment of neuroblastoma. This study has investigated the biological variation in handling of the compound in children with neuroblastoma. The biodistribution of the compound has been characterised in children undergoing tracer administrations of 123I and 131I-mIBG. Estimates of hepatic and whole body radiation dose delivery have been made. The results indicate substantial interpatient variation in hepatic dose delivery. This organ may be critical in some patients undergoing targeted radiotherapy with mIBG.
间碘苄胍（MIBG）在神经母细胞瘤治疗方面引发了极大关注。本研究调查了神经母细胞瘤患儿对该化合物处理过程中的生物学差异。已对接受123I和131I - MIBG示踪剂给药的患儿体内该化合物的生物分布进行了表征。已对肝脏和全身的辐射剂量传递进行了估算。结果表明，患者之间肝脏剂量传递存在显著差异。在一些接受MIBG靶向放疗的患者中，该器官可能至关重要。
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