The Joint Department of Physics, The Royal Marsden NHS Foundation Trust & Institute of Cancer Research, Sutton, United Kingdom.
Br J Radiol. 2022 Jul 1;95(1135):20220056. doi: 10.1259/bjr.20220056. Epub 2022 May 12.
Nuclear Medicine therapy has reached a critical juncture with an unprecedented number of patients being treated and an extensive list of new radiopharmaceuticals under development. Since the early applications of these treatments dosimetry has played a vital role in their development, in both aiding optimisation and enhancing safety and efficacy. To inform the future direction of this field, it is useful to reflect on the scientific and technological advances that have occurred since those early uses. In this review, we explore how dosimetry has evolved over the years and discuss why such initiatives were conceived and the importance of maintaining standards within our practise. Specific milestones and landmark publications are highlighted and a thematic review and significant outcomes during each decade are presented.
核医学治疗已经到了一个关键的时刻，有大量的患者接受治疗，大量新的放射性药物正在开发中。自这些治疗方法的早期应用以来，剂量学在其发展中发挥了至关重要的作用，既有助于优化，又提高了安全性和疗效。为了为这一领域的未来发展提供信息，回顾一下自早期应用以来发生的科学技术进步是很有用的。在这篇综述中，我们探讨了剂量学多年来是如何发展的，并讨论了为什么会有这样的设想，以及在我们的实践中保持标准的重要性。我们强调了特定的里程碑和标志性出版物，并对每个十年的主题综述和重要结果进行了介绍。
