• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

使用解扰群进行神经网络解释。

Neural network interpretation using descrambler groups.

机构信息

School of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom.

School of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom

出版信息

Proc Natl Acad Sci U S A. 2021 Feb 2;118(5). doi: 10.1073/pnas.2016917118.

DOI:10.1073/pnas.2016917118
PMID:33500352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7865153/
Abstract

The lack of interpretability and trust is a much-criticized feature of deep neural networks. In fully connected nets, the signaling between inner layers is scrambled because backpropagation training does not require perceptrons to be arranged in any particular order. The result is a black box; this problem is particularly severe in scientific computing and digital signal processing (DSP), where neural nets perform abstract mathematical transformations that do not reduce to features or concepts. We present here a group-theoretical procedure that attempts to bring inner-layer signaling into a human-readable form, the assumption being that this form exists and has identifiable and quantifiable features-for example, smoothness or locality. We applied the proposed method to DEERNet (a DSP network used in electron spin resonance) and managed to descramble it. We found considerable internal sophistication: the network spontaneously invents a bandpass filter, a notch filter, a frequency axis rescaling transformation, frequency-division multiplexing, group embedding, spectral filtering regularization, and a map from harmonic functions into Chebyshev polynomials-in 10 min of unattended training from a random initial guess.

摘要

深度神经网络缺乏可解释性和可信任性,这是饱受批评的一点。在全连接网络中,由于反向传播训练不需要按特定顺序排列感知机,因此内部层之间的信号传递是混乱的。结果是一个黑盒;这个问题在科学计算和数字信号处理 (DSP) 中尤为严重,在这些领域中,神经网络执行抽象的数学变换,而这些变换不能简化为特征或概念。我们在这里提出了一种群论方法,试图将内部层的信号传递转化为人类可读的形式,假设这种形式存在,并且具有可识别和可量化的特征,例如平滑度或局部性。我们将所提出的方法应用于 DEERNet(一种用于电子自旋共振的 DSP 网络),并成功地对其进行了去混淆。我们发现了相当大的内部复杂性:该网络自发地发明了带通滤波器、陷波滤波器、频率轴重采样变换、频分复用、分组嵌入、频谱滤波正则化,以及将调和函数映射到切比雪夫多项式的映射——在没有人工干预的情况下,从随机初始猜测进行 10 分钟的训练。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/472c56196b91/pnas.2016917118fig06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/418d353b09fa/pnas.2016917118fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/23c7ee8b09bc/pnas.2016917118fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/a0cf83b44c76/pnas.2016917118fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/3780d245ff6c/pnas.2016917118fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/90bdb629d6b0/pnas.2016917118fig05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/472c56196b91/pnas.2016917118fig06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/418d353b09fa/pnas.2016917118fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/23c7ee8b09bc/pnas.2016917118fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/a0cf83b44c76/pnas.2016917118fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/3780d245ff6c/pnas.2016917118fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/90bdb629d6b0/pnas.2016917118fig05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dcd/7865153/472c56196b91/pnas.2016917118fig06.jpg

相似文献

1
Neural network interpretation using descrambler groups.使用解扰群进行神经网络解释。
Proc Natl Acad Sci U S A. 2021 Feb 2;118(5). doi: 10.1073/pnas.2016917118.
2
A deep dive into understanding tumor foci classification using multiparametric MRI based on convolutional neural network.基于卷积神经网络,深入探究利用多参数磁共振成像进行肿瘤病灶分类。
Med Phys. 2020 Sep;47(9):4077-4086. doi: 10.1002/mp.14255. Epub 2020 Jun 12.
3
Nonlinear dynamic system identification using Chebyshev functional link artificial neural networks.基于切比雪夫函数链接人工神经网络的非线性动态系统辨识
IEEE Trans Syst Man Cybern B Cybern. 2002;32(4):505-11. doi: 10.1109/TSMCB.2002.1018769.
4
DANTE: Deep alternations for training neural networks.DANTE:深度神经网络训练的交替法。
Neural Netw. 2020 Nov;131:127-143. doi: 10.1016/j.neunet.2020.07.026. Epub 2020 Jul 28.
5
Development and validation of an interpretable neural network for prediction of postoperative in-hospital mortality.用于预测术后院内死亡率的可解释神经网络的开发与验证
NPJ Digit Med. 2021 Jan 8;4(1):8. doi: 10.1038/s41746-020-00377-1.
6
Novel deep neural network based pattern field classification architectures.基于新型深度神经网络的模式场分类架构。
Neural Netw. 2020 Jul;127:82-95. doi: 10.1016/j.neunet.2020.03.011. Epub 2020 Mar 14.
7
A more biologically plausible learning rule than backpropagation applied to a network model of cortical area 7a.一种比反向传播更具生物学合理性的学习规则,应用于皮层7a区的网络模型。
Cereb Cortex. 1991 Jul-Aug;1(4):293-307. doi: 10.1093/cercor/1.4.293.
8
Micrometer Backstepping Control System for Linear Motion Single Axis Robot Machine Drive.用于直线运动单轴机器人机械驱动的微米级反步控制系统。
Sensors (Basel). 2019 Aug 20;19(16):3616. doi: 10.3390/s19163616.
9
An Interactive Visualization for Feature Localization in Deep Neural Networks.一种用于深度神经网络中特征定位的交互式可视化方法。
Front Artif Intell. 2020 Jul 23;3:49. doi: 10.3389/frai.2020.00049. eCollection 2020.
10
Data Integration Using Advances in Machine Learning in Drug Discovery and Molecular Biology.利用机器学习进展进行药物发现和分子生物学中的数据整合
Methods Mol Biol. 2021;2190:167-184. doi: 10.1007/978-1-0716-0826-5_7.

引用本文的文献

1
High-confidence reconstruction for Laplace inversion in NMR based on uncertainty-informed deep learning.基于不确定性感知深度学习的核磁共振拉普拉斯反演的高置信度重建
Sci Adv. 2025 Aug 29;11(35):eadw1379. doi: 10.1126/sciadv.adw1379. Epub 2025 Aug 27.
2
An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal.一种增强型转录因子阻遏振荡器,可缓冲随机性并与不稳定的外部昼夜节律信号同步。
Front Syst Biol. 2023 Dec 13;3:1276734. doi: 10.3389/fsysb.2023.1276734. eCollection 2023.
3
The ABC transporter MsbA adopts the wide inward-open conformation in cells.

本文引用的文献

1
Deep neural network processing of DEER data.DEER数据的深度神经网络处理
Sci Adv. 2018 Aug 24;4(8):eaat5218. doi: 10.1126/sciadv.aat5218. eCollection 2018 Aug.
2
Modeling of the N-terminal Section and the Lumenal Loop of Trimeric Light Harvesting Complex II (LHCII) by Using EPR.利用电子顺磁共振对三聚体光系统II捕光复合体(LHCII)的N端区域和腔内环进行建模。
J Biol Chem. 2015 Oct 23;290(43):26007-20. doi: 10.1074/jbc.M115.669804. Epub 2015 Aug 27.
3
DEER distance measurements on proteins.蛋白质的双电子-电子共振距离测量。
ABC 转运蛋白 MsbA 在 细胞中采取宽向内开放构象。
Sci Adv. 2022 Oct 14;8(41):eabn6845. doi: 10.1126/sciadv.abn6845. Epub 2022 Oct 12.
4
Cross-validation of distance measurements in proteins by PELDOR/DEER and single-molecule FRET.通过 PELDOR/DEER 和单分子 FRET 对蛋白质中的距离测量进行交叉验证。
Nat Commun. 2022 Jul 29;13(1):4396. doi: 10.1038/s41467-022-31945-6.
5
Is There a Need for a More Precise Description of Biomolecule Interactions to Understand Cell Function?是否需要对生物分子相互作用进行更精确的描述以理解细胞功能?
Curr Issues Mol Biol. 2022 Jan 21;44(2):505-525. doi: 10.3390/cimb44020035.
6
Towards autonomous analysis of chemical exchange saturation transfer experiments using deep neural networks.使用深度神经网络实现化学交换饱和转移实验的自主分析。
J Biomol NMR. 2022 Jun;76(3):75-86. doi: 10.1007/s10858-022-00395-z. Epub 2022 May 27.
7
Deep-Learning-Assisted Focused Ion Beam Nanofabrication.深度学习辅助聚焦离子束纳米加工。
Nano Lett. 2022 Apr 13;22(7):2734-2739. doi: 10.1021/acs.nanolett.1c04604. Epub 2022 Mar 24.
8
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations.从 DEER 数据的严格全局分析中获取蛋白质功能动力学:条件、组成和构象。
J Gen Physiol. 2021 Nov 1;153(11). doi: 10.1085/jgp.201711954. Epub 2021 Sep 16.
9
FID-Net: A versatile deep neural network architecture for NMR spectral reconstruction and virtual decoupling.FID-Net:一种用于 NMR 谱重构和虚拟去耦的多功能深度神经网络架构。
J Biomol NMR. 2021 May;75(4-5):179-191. doi: 10.1007/s10858-021-00366-w. Epub 2021 Apr 19.
Annu Rev Phys Chem. 2012;63:419-46. doi: 10.1146/annurev-physchem-032511-143716. Epub 2012 Jan 30.